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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 05:41, 23 November 2010
, 05:41, 23 November 2010→Alzheimer disease: +ref
m (→Microscopic) |
(→Alzheimer disease: +ref) |
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**Lateral ventricles. | **Lateral ventricles. | ||
**Third ventricle. | **Third ventricle. | ||
Gross/microscopic - disease spread by NF tangles (staging):<ref name=pmid8307060>{{cite journal |author=Braak H, Braak E, Bohl J |title=Staging of Alzheimer-related cortical destruction |journal=Eur. Neurol. |volume=33 |issue=6 |pages=403–8 |year=1993 |pmid=8307060 |doi= |url=}}</ref> | |||
*Alzheimer "spreads" in a reproducible pattern: | |||
**Stage I-II: entorhinal cortex. | |||
**Stage III-IV: inferior aspect of brain. | |||
**Stage V-VI: limbic system. | |||
===Microscopic=== | ===Microscopic=== | ||
| Line 188: | Line 194: | ||
#*#Neurites - swollen axons. | #*#Neurites - swollen axons. | ||
#*Considered to be more specific for Alzheimer's than NF tangles. | #*Considered to be more specific for Alzheimer's than NF tangles. | ||
#*There is a staging system for plaques I (mild), II (moderate), III (severe). | |||
Notes: | Notes: | ||
| Line 197: | Line 204: | ||
*Tau: | *Tau: | ||
**Important in microtubule assembly. | **Important in microtubule assembly. | ||
==Lewy body diseases== | ==Lewy body diseases== | ||