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Neuropathology tumours (view source)
Revision as of 03:21, 23 November 2010
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==Medulloblastoma== | ==Medulloblastoma== | ||
===General=== | ===General=== | ||
* | *Mostly paediatric population. | ||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm]. Accessed on: 26 October 2010.</ref> | Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm]. Accessed on: 26 October 2010.</ref> | ||
*Homer-Wright rosettes. | *Homer-Wright rosettes= rosette with a meshwork of fibers (neuropil) at the centre.<ref>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
Image: | Image: | ||
*[http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm Medulloblastoma (ouhsc.edu)]. | *[http://moon.ouhsc.edu/kfung/jty1/neurotest/Q93-Ans.htm Medulloblastoma (ouhsc.edu)]. | ||
====Subtypes==== | |||
*Classic medulloblastoma (~85% of all medulloblastomas). | |||
*Variants of medulloblastoma (~15% of all medulloblastomas together): | |||
*#Anaplastic variant. | |||
*#Large cell variant. | |||
*#Desmoplastic/nodular medulloblastoma (DNMB). | |||
*#Medulloblastoma with extensive nodularity (MBEN). | |||
Notes: | |||
*Prognosis:<ref name=pmid18841049>{{cite journal |author=Gulino A, Arcella A, Giangaspero F |title=Pathological and molecular heterogeneity of medulloblastoma |journal=Curr Opin Oncol |volume=20 |issue=6 |pages=668–75 |year=2008 |month=November |pmid=18841049 |doi=10.1097/CCO.0b013e32831369f4 |url=}}</ref><ref name=pmid20940197>{{cite journal |author=Rutkowski S, von Hoff K, Emser A, ''et al.'' |title=Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis |journal=J Clin Oncol |volume=28 |issue=33 |pages=4961–4968 |year=2010 |month=November |pmid=20940197 |doi=10.1200/JCO.2010.30.2299 |url=}}</ref> DNMB & MBEN > classic > anaplastic variant, large cell variant. | |||
==See also== | ==See also== | ||
*[[Neuropathology]]. | *[[Neuropathology]]. | ||