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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 19:30, 20 November 2010
, 19:30, 20 November 2010TDP-43
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(TDP-43) |
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| '''Distribution''' | | '''Distribution''' | ||
| '''Clinical''' | | '''Clinical''' | ||
| '''Histology''' | |||
| '''Image''' | | '''Image''' | ||
|- | |- | ||
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| corticolimbic, usu. <br>spares occipital | | corticolimbic, usu. <br>spares occipital | ||
| dementia | | dementia | ||
| histology? | |||
| Image? | | Image? | ||
|- | |- | ||
| Line 52: | Line 54: | ||
| cortical & basal ganglia | | cortical & basal ganglia | ||
| dementia (rapid progression), <br>movement disorder | | dementia (rapid progression), <br>movement disorder | ||
| plaques, neurofibrillary tangles ??? | |||
| Image? | | Image? | ||
|- | |- | ||
| Line 58: | Line 61: | ||
| basal ganglia, brainstem | | basal ganglia, brainstem | ||
| parkinsonism | | parkinsonism | ||
| histology? | |||
| Image? | | Image? | ||
|- | |- | ||
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| corticolimbic | | corticolimbic | ||
| dementia + focal <br>cortical syndrome | | dementia + focal <br>cortical syndrome | ||
| Pick body ??? | |||
| Image? | | Image? | ||
|- | |- | ||
| Line 70: | Line 75: | ||
| brainstem | | brainstem | ||
| parkinsonism | | parkinsonism | ||
| histology? | |||
| Image? | | Image? | ||
|- | |- | ||
| Line 76: | Line 82: | ||
| corticolimbic, brainstem | | corticolimbic, brainstem | ||
| dementia + parkinsonism | | dementia + parkinsonism | ||
| histology? | |||
| Image? | | Image? | ||
|- | |- | ||
| Line 82: | Line 89: | ||
| basal ganglia, brainstem, cerebellum | | basal ganglia, brainstem, cerebellum | ||
| parkinsonism, ataxia | | parkinsonism, ataxia | ||
| histology? | |||
| Image | | Image | ||
|- | |- | ||
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| motor neurons | | motor neurons | ||
| spasticity, weakness | | spasticity, weakness | ||
| histology? | |||
| Image | | Image | ||
|- | |- | ||
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| cortex, basal ganglia | | cortex, basal ganglia | ||
| dementia, focal cortical syndromes | | dementia, focal cortical syndromes | ||
| histology? | |||
| Image? | | Image? | ||
|- <!-- | |- <!-- | ||
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| Distribution | | Distribution | ||
| Clinical | | Clinical | ||
| histology? | |||
| Image --> | | Image --> | ||
|} | |} | ||
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*AT-8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | *AT-8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | ||
*p62; poli-ubiquitin-binding protein p62.<ref name=pmid19946779/> | *p62; poli-ubiquitin-binding protein p62.<ref name=pmid19946779/> | ||
*TDP-43. | *TDP-43 - normally in the nucleus. | ||
**Pathologic:<ref>URL: [http://archneur.ama-assn.org/cgi/content/full/65/5/636/NOC70108F2 http://archneur.ama-assn.org/cgi/content/full/65/5/636/NOC70108F2]. Accessed on: 20 November 2010.</ref> | |||
***''Fibrillar'' or ''skein-like formations'' = cytoplasmic staining. | |||
***''Neurites'' = squiggly appearance. | |||
==Clinical perspective (becoming obsolete)== | ==Clinical perspective (becoming obsolete)== | ||