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Difference between revisions of "Papillary urothelial hyperplasia"
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Papillary urothelial hyperplasia (view source)
Revision as of 19:32, 27 January 2014
, 19:32, 27 January 2014no edit summary
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*Benign. | *Benign. | ||
*Strong association with papillary neoplasms. | *Strong association with papillary neoplasms. | ||
**On follow-up | **On follow-up (in one study) >1/4, without prior history of urothelial neoplasia, have urothelial carcinoma; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | ||
*Inflammation. | *Inflammation. | ||
*Rare | *Rare papillary structures. | ||
**Do not have a well-developed fibrovascular core. | **Do not have a well-developed fibrovascular core. | ||
*No urothelial cell atypia. | *No urothelial cell atypia. | ||
DDx: | DDx: | ||
*[[Low-grade papillary urothelial carcinoma]]. | *[[Low-grade papillary urothelial carcinoma]] - have well-developed fibrovascular core. | ||
*[[PUNLMP]]. | *[[PUNLMP]]. | ||
*[[Urothelial papilloma]]. | *[[Urothelial papilloma]] - well-developed fibrovascular cores, uniform urothelial thickness. | ||
===Image=== | ===Image=== | ||
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The urothelium stains as follow: | The urothelium stains as follow: | ||
CK7: positive ( | CK7: positive, patchy (normal). | ||
CK20: | CK20: only rare superficial cells (normal). | ||
Ki-67: rare, focally increased, negative in papillary structures (<10%). | Ki-67: rare, focally increased, negative in papillary structures (<10%). | ||
p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). | p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). | ||