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Difference between revisions of "Lymphoma"
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→Intravascular large B-cell lymphoma
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*Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in [[Hodgkin lymphoma]]. | *Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in [[Hodgkin lymphoma]]. | ||
==Intravascular large B-cell lymphoma== | ==Intravascular lymphoma== | ||
===General=== | *Rare. | ||
*Usually B-cell lineage (see below ''intravascular large B-cell lymphoma''). | |||
**May be T-cell lineage.<ref name=pmid20337769>{{cite journal |author=Wang L, Li C, Gao T |title=Cutaneous intravascular anaplastic large cell lymphoma |journal=J Cutan Pathol |volume= |issue= |pages= |year=2010 |month=March |pmid=20337769 |doi=10.1111/j.1600-0560.2010.01538.x |url=}}</ref> | |||
===Intravascular large B-cell lymphoma=== | |||
====General==== | |||
*[[AKA]] ''angiotropic lymphoma'', ''intravascular malignant lymphomatosis'', ''malignant angioendotheliomatosis''. | *[[AKA]] ''angiotropic lymphoma'', ''intravascular malignant lymphomatosis'', ''malignant angioendotheliomatosis''. | ||
====Clinical==== | =====Clinical===== | ||
*Often a non-specific presentation.<ref name=pmid11579120>{{cite journal |author=Lapkuviene O, Forchetti D, Roepke JE |title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms |journal=J. Clin. Oncol. |volume=19 |issue=19 |pages=3988–91 |year=2001 |month=October |pmid=11579120 |doi= |url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref> | *Often a non-specific presentation.<ref name=pmid11579120>{{cite journal |author=Lapkuviene O, Forchetti D, Roepke JE |title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms |journal=J. Clin. Oncol. |volume=19 |issue=19 |pages=3988–91 |year=2001 |month=October |pmid=11579120 |doi= |url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref> | ||
**+/-Fever. | **+/-Fever. | ||
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**+/-Non-specific skin lesions. | **+/-Non-specific skin lesions. | ||
===Microscopic=== | ====Microscopic==== | ||
Features: | Features: | ||
*Abundant atypical intravascular lymphoid cells that are: | *Abundant atypical intravascular lymphoid cells that are: | ||
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*[http://annonc.oxfordjournals.org/content/13/9/1503/F1.expansion.html ILBCL - various images (oxfordjournals.org)]. | *[http://annonc.oxfordjournals.org/content/13/9/1503/F1.expansion.html ILBCL - various images (oxfordjournals.org)]. | ||
===IHC=== | ====IHC==== | ||
Features:<ref name=pmid11579120/> | Features:<ref name=pmid11579120/> | ||
*CD20 +ve - '''key feature'''. | *CD20 +ve - '''key feature'''. | ||