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Difference between revisions of "Pseudomembranous colitis"
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Pseudomembranous colitis (view source)
Revision as of 02:15, 13 January 2014
, 02:15, 13 January 2014no edit summary
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| Width = | | Width = | ||
| Caption = Colonic pseudomembrane. [[H&E stain]]. | | Caption = Colonic pseudomembrane. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = ''C. difficle colitis'' commonly used as synonym by clinicians - ''not'' the same from the same for the perspective of pathology | ||
| Micro = heaped necrotic surface epithelium (described as "volanco lesions"), [[PMN]]s in lamina propria, +/-capillary fibrin thrombi | | Micro = heaped necrotic surface epithelium (described as "volanco lesions"), [[PMN]]s in lamina propria, +/-capillary fibrin thrombi | ||
| Subtypes = | | Subtypes = | ||
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| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = diarrhea, abdominal pain, fever | ||
| Prevalence = uncommon | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
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| Endoscopy = pseudomembranes (pale yellow (or white) irregular, raised mucosal lesions), interlesional mucosa often near normal grossly | | Endoscopy = pseudomembranes (pale yellow (or white) irregular, raised mucosal lesions), interlesional mucosa often near normal grossly | ||
| Prognosis = dependent on comorbidities | | Prognosis = dependent on comorbidities | ||
| Other = | | Other = ''C. difficile'' toxin test positive (may be negative) | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = dependent on underlying cause, antibiotics in ''C. difficle'' - occasionally surgical resection | | Tx = dependent on underlying cause, antibiotics in ''C. difficle'' - occasionally surgical resection | ||
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Etiology: | Etiology: | ||
*Anything that causes a severe mucosal injury. | *Anything that causes a severe mucosal injury. | ||
Epidemiology of ''[[C. difficle]]'' pseudomembranous colitis: | |||
*Antibiotics prior to onset (classic history).<ref name=pmid23253319>{{Cite journal | last1 = Bassetti | first1 = M. | last2 = Villa | first2 = G. | last3 = Pecori | first3 = D. | last4 = Arzese | first4 = A. | last5 = Wilcox | first5 = M. | title = Epidemiology, diagnosis and treatment of Clostridium difficile infection. | journal = Expert Rev Anti Infect Ther | volume = 10 | issue = 12 | pages = 1405-23 | month = Dec | year = 2012 | doi = 10.1586/eri.12.135 | PMID = 23253319 }}</ref> | |||
==Gross== | ==Gross== | ||