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Difference between revisions of "Squamous cell carcinoma of the lung"
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Squamous cell carcinoma of the lung (view source)
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'''Squamous cell carcinoma of the lung''', also '''lung squamous cell carcinoma''', is a common [[cancer|malignant]] [[lung tumour]] that is associated with [[smoking]]. | |||
==General== | |||
*Strong association with [[smoking]]. | |||
*May be treated with surgery. | |||
==Gross== | |||
*Usually centrally located, i.e. large airways. | |||
==Microscopic== | |||
Features: | |||
*Central nucleus. | |||
*Dense appearing cytoplasm, usu. eosinophilic. | |||
*+/-Small nucleolus. | |||
DDx: | |||
*Metastatic [[squamous cell carcinoma]]. | |||
*[[Adenocarcinoma of the lung]]. | |||
*[[Non-small cell lung carcinoma]] - diagnosis should be avoid if possible. | |||
==IHC== | |||
*p40 +ve.<ref name=pmid22056955>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref> | |||
**p63 +ve -- less specific. | |||
*TTF-1 -ve. | |||
**Positive in adenocarcinoma. | |||
*Calponin -ve. | |||
*CK5/6 +ve. | |||
==See also== | |||
*[[Squamous cell carcinoma]]. | |||
*[[Lung tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Lung tumours]] | |||