Difference between revisions of "Lung tumours"

Lung tumours (view source)

948 bytes removed , 03:27, 12 January 2014

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 ==Squamous cell carcinoma of the lung==
-{{Main|Squamous cell carcinoma}}
+{{Main|Squamous cell carcinoma of the lung}}
-===General===
-*Strong association with smoking.
-*May be treated with surgery.
-===Microscopic===
-Features:
-*Central nucleus.
-*Dense appearing cytoplasm, usu. eosinophilic.
-*+/-Small nucleolus.
-DDx:
-*Metastatic [[squamous cell carcinoma]].
-*[[Adenocarcinoma of the lung]].
-*[[Non-small cell lung carcinoma]] - diagnosis should be avoid if possible.
-===IHC===
-*p40 +ve.<ref name=pmid22056955>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref>
-**p63 +ve -- less specific.
-*TTF-1 -ve.
-**Positive in adenocarcinoma.
-*Calponin -ve.
-*CK5/6 +ve.
 ==Small cell carcinoma of the lung==