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Sex cord tumour with annular tubules (view source)
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'''Sex cord tumour with annular tubules''', abbreviated '''SCTAT''', is an uncommon sex cord tumour. | |||
It is '''not''' ''sex cord tumour with angulated tubules''. | |||
==General== | |||
*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid7358344>{{Cite journal | last1 = Purohit | first1 = RC. | last2 = Alam | first2 = SZ. | title = Sex cord tumour of the ovary with annular tubules (SCTAT). | journal = Histopathology | volume = 4 | issue = 2 | pages = 147-54 | month = Mar | year = 1980 | doi = | PMID = 7358344 }}</ref> | |||
**Large tumours more likely sporadic. | |||
**Small tumours more likely Peutz-Jeghers syndrome and incidental. | |||
*Usually benign. | |||
**Malignant cases reported.<ref name=pmid10786816>{{Cite journal | last1 = Lele | first1 = SM. | last2 = Sawh | first2 = RN. | last3 = Zaharopoulos | first3 = P. | last4 = Adesokan | first4 = A. | last5 = Smith | first5 = M. | last6 = Linhart | first6 = JM. | last7 = Arrastia | first7 = CD. | last8 = Krigman | first8 = HR. | title = Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report. | journal = Mod Pathol | volume = 13 | issue = 4 | pages = 466-70 | month = Apr | year = 2000 | doi = 10.1038/modpathol.3880079 | PMID = 10786816 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Well-circumscribed nests of cells with nuclei at the periphery. | |||
*Annular tubules (ring-shaped tubules) with dense hyaline material. | |||
Notes: | |||
*''Annular'' = shape of a ring.<ref>URL: [http://dictionary.reference.com/browse/annular http://dictionary.reference.com/browse/annular]. Accessed on: 6 August 2011.</ref> | |||
*May focally have features of [[Sertoli cell tumour]] or [[granulosa cell tumour]].<ref name=pmid7104978>{{Cite journal | last1 = Young | first1 = RH. | last2 = Welch | first2 = WR. | last3 = Dickersin | first3 = GR. | last4 = Scully | first4 = RE. | title = Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix. | journal = Cancer | volume = 50 | issue = 7 | pages = 1384-402 | month = Oct | year = 1982 | doi = | PMID = 7104978 }} | |||
</ref> | |||
DDx: | |||
*Sertoli-Leydig tumour - has double palisading with overlap of the layers. | |||
*[[Granulosa cell tumour]] - have Call-Exner bodies, which don't have a well-defined/solid content. | |||
*[[Brenner tumour]] - [[coffee-bean nuclei]]. | |||
===Images=== | |||
www: | |||
*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=10&cat2=120&cat3=1015&cat4=3&stype=n SCTAT - image collection (gfmer.ch)]. | |||
*[http://www.pathology.cn/bbs/forum.php?mod=viewthread&tid=57445 Possible SCTAT (pathology.cn)]. | |||
<gallery> | |||
Image:Sex_cord_tumour_with_annular_tubules_-_intermed_mag.jpg | SCTAT - intermed. mag. (WC) | |||
Image:Sex_cord_tumour_with_annular_tubules_-_high_mag.jpg | SCTAT - high mag. (WC) | |||
Image:Sex_cord_tumour_with_annular_tubules_-_very_high_mag.jpg | SCTAT - very high mag. (WC) | |||
Image:Sex_cord_tumour_with_annular_tubules_-_2_-_very_high_mag.jpg | SCTAT - very high mag. (WC) | |||
</gallery> | |||
==See also== | |||
*[[Ovarian tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Ovarian tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||