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Difference between revisions of "Neuropathology tumours"
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Neuropathology tumours (view source)
Revision as of 23:21, 15 November 2010
, 23:21, 15 November 2010→Astrocytomas
m (→Oligodendroglioma: clarify) |
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*Microvascular proliferation ''or'' necrosis with pseudopalisading tumour cells. | *Microvascular proliferation ''or'' necrosis with pseudopalisading tumour cells. | ||
**Pseudopalisading tumour cells = high tumour cell density adjacent to regions of necrosis; palisade = a fence of pales forming a defense barrier or fortification. | **Pseudopalisading tumour cells = high tumour cell density adjacent to regions of necrosis; palisade = a fence of pales forming a defense barrier or fortification. | ||
===Glioblastoma IHC=== | |||
*GFAP - should stain cytoplasm of tumour cells and the perikaryon (nuclear membrane). | |||
*Ki-67. | |||
*p53. | |||
*IDH1. | |||
**+ve in tumours that arose from low-grade gliomas.<ref name=pmid19228619>PMID 19228619.</ref> | |||
Notes: | |||
*IDH1 and IDH2 mutations - better survival.<ref name=pmid20975057>PMID 20975057.</ref> | |||
==Pilocytic astrocytoma== | ==Pilocytic astrocytoma== | ||