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Difference between revisions of "Meningioma"
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→IHC
(→IHC: more) |
(→IHC) |
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*Other CKs usually -ve. | *Other CKs usually -ve. | ||
DDx of meningioma & IHC | ===DDx of meningioma & IHC<ref name=pmid16393681>{{cite journal |author=Hahn HP, Bundock EA, Hornick JL |title=Immunohistochemical staining for claudin-1 can help distinguish meningiomas from histologic mimics |journal=Am. J. Clin. Pathol. |volume=125 |issue=2 |pages=203–8 |year=2006 |month=February |pmid=16393681 |doi=10.1309/G659-FVVB-MG7U-4RPQ |url=http://ajcp.ascpjournals.org/content/125/2/203.full.pdf}}</ref>=== | ||
*S-100 +ve - schwannoma. | *S-100 +ve - schwannoma. | ||
**+ve in ~80% of fibrous meningiomas. | **+ve in ~80% of fibrous meningiomas. | ||
*CD34 +ve - solitary fibrous tumour. | *CD34 +ve - solitary fibrous tumour. | ||
**+ve in ~60% of fibrous meningiomas. | **+ve in ~60% of fibrous meningiomas. | ||
*EMA +ve in ~30% of hemangiopericytoma. | *EMA +ve in ~30% of hemangiopericytoma. | ||
*Claudin-1 - new kid on the block: +ve in meningioma, but low sensitivity. | *Claudin-1 - new kid on the block: +ve in meningioma, but low sensitivity. | ||