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Difference between revisions of "Liposarcoma"
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| Caption = Liposarcoma. [[H&E stain]]. | | Caption = Liposarcoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = lipoblasts - '''key feature''', chicken wire-like vascular, +/-[[myxoid]] background, cell size variation, thick fibrous septa (important low power feature) | ||
| Subtypes = | | Subtypes = [[dedifferentiated liposarcoma]], [[myxoid liposarcoma]] (includes round cell liposarcoma), mixed-type liposarcoma, pleomorphic liposarcoma, liposarcoma not otherwise specified (NOS), spindle cell liposarcoma | ||
| LMDDx = [[pleomorphic undifferentiated sarcoma]] | | LMDDx = [[pleomorphic undifferentiated sarcoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = S-100 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = t(12;16)(q13;p11) / TLS-CHOP -- for myxoid liposarcoma | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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| Prevalence = most common retroperitoneal sarcoma, uncommon overall | | Prevalence = most common retroperitoneal sarcoma, uncommon overall | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = thick septae | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = poor | | Prognosis = poor | ||
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**Extremely rare in retroperitoneum: [[synovial sarcoma]]. | **Extremely rare in retroperitoneum: [[synovial sarcoma]]. | ||
==Gross== | |||
*Thick fibrous septa | |||
Radiology:<ref name=pmid9108224/> | |||
*Fibrous septa or nodules.<ref name=pmid16160117>{{Cite journal | last1 = Murphey | first1 = MD. | last2 = Arcara | first2 = LK. | last3 = Fanburg-Smith | first3 = J. | title = From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. | journal = Radiographics | volume = 25 | issue = 5 | pages = 1371-95 | month = | year = | doi = 10.1148/rg.255055106 | PMID = 16160117 }}</ref> | |||
*Myoid liposarcoma - high signal (due to high water content).<ref name=pmid16160117/> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
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*+/-[[Myxoid]] background. | *+/-[[Myxoid]] background. | ||
*Cell size variation. | *Cell size variation. | ||
*Thick fibrous septa - important low power feature.<ref name=pmid9108224>{{Cite journal | last1 = Hosono | first1 = M. | last2 = Kobayashi | first2 = H. | last3 = Fujimoto | first3 = R. | last4 = Kotoura | first4 = Y. | last5 = Tsuboyama | first5 = T. | last6 = Matsusue | first6 = Y. | last7 = Nakamura | first7 = T. | last8 = Itoh | first8 = T. | last9 = Konishi | first9 = J. | title = Septum-like structures in lipoma and liposarcoma: MR imaging and pathologic correlation. | journal = Skeletal Radiol | volume = 26 | issue = 3 | pages = 150-4 | month = Mar | year = 1997 | doi = | PMID = 9108224 }}</ref> | |||
DDx: | DDx: | ||