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Difference between revisions of "Small cell carcinoma of the lung"
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Small cell carcinoma of the lung (view source)
Revision as of 14:14, 5 January 2014
, 14:14, 5 January 2014no edit summary
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Lung_small_cell_carcinoma_%281%29_by_core_needle_biopsy.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Lung small cell carcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = stippled chromatin, high [[NC ratio]] with scant basophilic cytoplasm, typically small cells (~2x [[RBC]] diameter), +/-nuclear moulding, smudgy appearance [[Azzopardi | | Micro = stippled chromatin, high [[NC ratio]] with scant basophilic cytoplasm, typically small cells (~2x [[RBC]] diameter), +/-nuclear moulding, nuclei with smudgy appearance ([[Azzopardi phenomenon]]), necrosis, [[mitoses]] | ||
| Subtypes = | | Subtypes = large cell neuroendocrine carcinoma (LCNEC) | ||
| LMDDx = | | LMDDx = poorly differentiated [[adenocarcinoma of the lung]], [[atypical carcinoid]], [[lung carcinoid]], metastatic [[small cell carcinoma]], [[lymphoma]], other [[small round blue cell tumours]] | ||
| Stains = chromogranin +ve, synaptophysin +ve, CD56 +ve, NSE +ve, TTF-1 +ve | | Stains = chromogranin +ve, synaptophysin +ve, CD56 +ve, NSE +ve, TTF-1 +ve | ||
| IHC = | | IHC = | ||
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| ClinDDx = other lung tumours ([[squamous cell carcinoma of the lung]]), metastatic tumours | | ClinDDx = other lung tumours ([[squamous cell carcinoma of the lung]]), metastatic tumours | ||
| Tx = medical (chemotherapy) | | Tx = medical (chemotherapy) | ||
} | }} | ||
'''Small cell carcinoma of the lung''', also '''small cell lung carcinoma''' (abbreviated '''SCLC''')<ref name=pmid20943645/> is an aggressive [[malignant]] [[Lung tumours|tumour of the lung]]. It is strongly associated with [[smoking]]. | '''Small cell carcinoma of the lung''', also '''small cell lung carcinoma''' (abbreviated '''SCLC''')<ref name=pmid20943645/> is an aggressive [[malignant]] [[Lung tumours|tumour of the lung]]. It is strongly associated with [[smoking]]. | ||
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*Typically small cells ~2x RBC diameter. | *Typically small cells ~2x RBC diameter. | ||
*+/-Nuclear moulding. | *+/-Nuclear moulding. | ||
*Necrosis. | *Nuclei with a smudgy appearance ([[Azzopardi phenomenon]]). | ||
*[[Necrosis]]. | |||
*Mitoses. | *Mitoses. | ||
Notes: | Notes: | ||
*There should be no nucleolus. | *There should be no [[nucleolus]]. | ||
DDx: | DDx: | ||
*Poorly differentiated [[adenocarcinoma of the lung]]. | |||
*Metastatic [[small cell carcinoma]]. | *Metastatic [[small cell carcinoma]]. | ||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
*[[Atypical carcinoid]]. | *[[Atypical carcinoid]]. | ||
*Other [[small round blue cell tumours]]. | *Other [[small round blue cell tumours]]. | ||
===Subtypes=== | |||
*Large cell neuroendocrine carcinoma (LCNEC). | *Large cell neuroendocrine carcinoma (LCNEC). | ||