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Difference between revisions of "Small cell carcinoma of the lung"
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Small cell carcinoma of the lung (view source)
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'''Small cell carcinoma of the lung''' is an aggressive [[malignant]] [[Lung tumours|tumour of the lung]]. It is strongly associated with [[smoking]]. | |||
==General== | |||
*Strong association with [[smoking]]. | |||
*Typically treated with chemotherapy. | |||
*Poor prognosis. | |||
On a spectrum of lesions (benign to malignant):<ref name=pmid20943645/> | |||
*[[lung tumourlet|Tumourlet]]. | |||
*[[typical carcinoid|Carcinoid]]. | |||
*[[atypical carcinoid|Atypical carcinoid]]. | |||
*Small cell carinoma/large cell neuroendocrine carcinoma. | |||
Precursor lesion - uncommonly seen: | |||
*Pulmonary neuroendocrine cell hyperplasia.<ref name=pmid20943645>{{Cite journal | last1 = Travis | first1 = WD. | title = Advances in neuroendocrine lung tumors. | journal = Ann Oncol | volume = 21 Suppl 7 | issue = | pages = vii65-71 | month = Oct | year = 2010 | doi = 10.1093/annonc/mdq380 | PMID = 20943645 }}</ref> | |||
==Gross== | |||
*Central location (close to large airways) - typical. | |||
*[[Necrosis]]. | |||
==Microscopic== | |||
Features: | |||
*Stippled chromatin. | |||
*High [[NC ratio]], scant basophilic cytoplasm. | |||
*Typically small cells ~2x RBC diameter. | |||
*+/-Nuclear moulding. | |||
*Necrosis. | |||
*Mitoses. | |||
Notes: | |||
*There should be no nucleolus. | |||
DDx: | |||
*Metastatic [[small cell carcinoma]]. | |||
*[[Lymphoma]]. | |||
*[[Atypical carcinoid]]. | |||
*Other [[small round blue cell tumours]]. | |||
*Large cell neuroendocrine carcinoma (LCNEC). | |||
===Images=== | |||
<gallery> | |||
Image:Lung_small_cell_carcinoma_%282%29_by_core_needle_biopsy.jpg | SCLC - low mag. (WC) | |||
Image:Lung_small_cell_carcinoma_%281%29_by_core_needle_biopsy.jpg | SCLC - high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
*Synaptophysin +ve. | |||
**May be very weak. | |||
*TTF-1 +ve (15 of 16 cases).<ref name=pmid16138374>{{Cite journal | last1 = Wu | first1 = M. | last2 = Szporn | first2 = AH. | last3 = Zhang | first3 = D. | last4 = Wasserman | first4 = P. | last5 = Gan | first5 = L. | last6 = Miller | first6 = L. | last7 = Burstein | first7 = DE. | title = Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers. | journal = Diagn Cytopathol | volume = 33 | issue = 4 | pages = 223-7 | month = Oct | year = 2005 | doi = 10.1002/dc.20337 | PMID = 16138374 }}</ref> | |||
==Sign out== | |||
<pre> | |||
LOWER LOBE OF LUNG, LEFT, CORE BIOPSY: | |||
- SMALL CELL CARCINOMA. | |||
</pre> | |||
==See also== | |||
*[[Small cell carcinoma]]. | |||
*[[Lung tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Lung tumours]] | |||