Difference between revisions of "Colorectal tumours"

Colorectal tumours (view source)

53 bytes added , 15:34, 3 January 2014

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 *Abbreviated ''MSI cancers''.
 ===General===
+*May be seen in [[Lynch syndrome]].
 Features:<ref name=pmid20420947>{{cite journal |author=Boland CR, Goel A |title=Microsatellite instability in colorectal cancer |journal=Gastroenterology |volume=138 |issue=6 |pages=2073–2087.e3 |year=2010 |month=June |pmid=20420947 |doi=10.1053/j.gastro.2009.12.064 |url=}}</ref>
 *Prognosis: slightly better than other [[CRC]] without MSI.
 *Treatment implication: different response to chemotherapy.
-Commonly associated abnormalities in the genes:
-#MLH1.
-#PMS2.
-#MSH2.
-#MSH6.
-Less common abnormalities:
-#PMS1.
-#MLH3.
-#MSH3.
 ====MSI classification====
@@ Line 142: / Line 134: @@
 **[[Signet ring cell carcinoma|Signet ring]].
 **Medullary.<ref name=pmid18283560>{{cite journal |author=Truta B, Chen YY, Blanco AM, ''et al.'' |title=Tumor histology helps to identify Lynch syndrome among colorectal cancer patients |journal=Fam. Cancer |volume=7 |issue=3 |pages=267–74 |year=2008 |pmid=18283560 |doi=10.1007/s10689-008-9186-8 |url=}}</ref>
+===Molecular===
+Commonly associated abnormalities in the genes:
+#MLH1.
+#PMS2.
+#MSH2.
+#MSH6.
+Less common abnormalities:
+#PMS1.
+#MLH3.
+#MSH3.
 ===IHC===