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===Grading=== | ===Grading=== | ||
Serous carcinoma is subdivided into:<ref name= | Serous carcinoma is subdivided into:<ref name=pmid19700937>{{Cite journal | last1 = Vang | first1 = R. | last2 = Shih | first2 = IeM. | last3 = Kurman | first3 = RJ. | title = Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. | journal = Adv Anat Pathol | volume = 16 | issue = 5 | pages = 267-82 | month = Sep | year = 2009 | doi = 10.1097/PAP.0b013e3181b4fffa | PMID = 19700937 }}</ref><ref name=pmid15087669>{{Cite journal | last1 = Malpica | first1 = A. | last2 = Deavers | first2 = MT. | last3 = Lu | first3 = K. | last4 = Bodurka | first4 = DC. | last5 = Atkinson | first5 = EN. | last6 = Gershenson | first6 = DM. | last7 = Silva | first7 = EG. | title = Grading ovarian serous carcinoma using a two-tier system. | journal = Am J Surg Pathol | volume = 28 | issue = 4 | pages = 496-504 | month = Apr | year = 2004 | doi = | PMID = 15087669 }}</ref> | ||
{| class="wikitable sortable" | |||
! Grade | |||
! Nuclei (most important) | |||
! Mitotic rate | |||
|- | |||
| Low-grade (Type I) | |||
| mild/moderate atypia | |||
| <=12 mitoses/HPF | |||
|- | |||
| High-grade (Type II) | |||
| severe atypia | |||
| >12 mitoses/HPF | |||
|} | |||
Note: | Note: | ||
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</gallery> | </gallery> | ||
www: | www: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716424/figure/F1/ Serous carcinoma - grade 1, 2 and 3 (nih.gov)].<ref name=pmid19461510>{{Cite journal | last1 = Ayhan | first1 = A. | last2 = Kurman | first2 = RJ. | last3 = Yemelyanova | first3 = A. | last4 = Vang | first4 = R. | last5 = Logani | first5 = S. | last6 = Seidman | first6 = JD. | last7 = Shih | first7 = IeM. | title = Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis. | journal = Am J Surg Pathol | volume = 33 | issue = 8 | pages = 1220-4 | month = Aug | year = 2009 | doi = 10.1097/PAS.0b013e3181a24354 | PMID = 19461510 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716424/figure/F1/ Serous carcinoma - grade 1, 2 and 3 (nih.gov)].<ref name=pmid19461510>{{Cite journal | last1 = Ayhan | first1 = A. | last2 = Kurman | first2 = RJ. | last3 = Yemelyanova | first3 = A. | last4 = Vang | first4 = R. | last5 = Logani | first5 = S. | last6 = Seidman | first6 = JD. | last7 = Shih | first7 = IeM. | title = Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis. | journal = Am J Surg Pathol | volume = 33 | issue = 8 | pages = 1220-4 | month = Aug | year = 2009 | doi = 10.1097/PAS.0b013e3181a24354 | PMID = 19461510 | PMC = 2716424 }}</ref> | ||
==IHC== | ==IHC== |
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