Difference between revisions of "Serous carcinoma of the ovary"

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===Grading===
===Grading===
Serous carcinoma is subdivided into:<ref name=pmid22833081>{{Cite journal  | last1 = Garg | first1 = K. | last2 = Park | first2 = KJ. | last3 = Soslow | first3 = RA. | title = Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: a report of 3 cases. | journal = Int J Gynecol Pathol | volume = 31 | issue = 5 | pages = 423-8 | month = Sep | year = 2012 | doi = 10.1097/PGP.0b013e31824ae6f2 | PMID = 22833081 }}</ref><ref name=pmid19700937>{{Cite journal  | last1 = Vang | first1 = R. | last2 = Shih | first2 = IeM. | last3 = Kurman | first3 = RJ. | title = Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. | journal = Adv Anat Pathol | volume = 16 | issue = 5 | pages = 267-82 | month = Sep | year = 2009 | doi = 10.1097/PAP.0b013e3181b4fffa | PMID = 19700937 }}</ref>
Serous carcinoma is subdivided into:<ref name=pmid19700937>{{Cite journal  | last1 = Vang | first1 = R. | last2 = Shih | first2 = IeM. | last3 = Kurman | first3 = RJ. | title = Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. | journal = Adv Anat Pathol | volume = 16 | issue = 5 | pages = 267-82 | month = Sep | year = 2009 | doi = 10.1097/PAP.0b013e3181b4fffa | PMID = 19700937 }}</ref><ref name=pmid15087669>{{Cite journal  | last1 = Malpica | first1 = A. | last2 = Deavers | first2 = MT. | last3 = Lu | first3 = K. | last4 = Bodurka | first4 = DC. | last5 = Atkinson | first5 = EN. | last6 = Gershenson | first6 = DM. | last7 = Silva | first7 = EG. | title = Grading ovarian serous carcinoma using a two-tier system. | journal = Am J Surg Pathol | volume = 28 | issue = 4 | pages = 496-504 | month = Apr | year = 2004 | doi = | PMID = 15087669 }}</ref>
*Low-grade (Type I).
{| class="wikitable sortable"
*High-grade (Type II).
! Grade
! Nuclei (most important)
! Mitotic rate
|-
| Low-grade (Type I)
| mild/moderate atypia
| <=12 mitoses/HPF
|-
| High-grade (Type II)
| severe atypia
| >12 mitoses/HPF
|}


Note:
Note:
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www:
www:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716424/figure/F1/ Serous carcinoma - grade 1, 2 and 3 (nih.gov)].<ref name=pmid19461510>{{Cite journal  | last1 = Ayhan | first1 = A. | last2 = Kurman | first2 = RJ. | last3 = Yemelyanova | first3 = A. | last4 = Vang | first4 = R. | last5 = Logani | first5 = S. | last6 = Seidman | first6 = JD. | last7 = Shih | first7 = IeM. | title = Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis. | journal = Am J Surg Pathol | volume = 33 | issue = 8 | pages = 1220-4 | month = Aug | year = 2009 | doi = 10.1097/PAS.0b013e3181a24354 | PMID = 19461510 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716424/figure/F1/ Serous carcinoma - grade 1, 2 and 3 (nih.gov)].<ref name=pmid19461510>{{Cite journal  | last1 = Ayhan | first1 = A. | last2 = Kurman | first2 = RJ. | last3 = Yemelyanova | first3 = A. | last4 = Vang | first4 = R. | last5 = Logani | first5 = S. | last6 = Seidman | first6 = JD. | last7 = Shih | first7 = IeM. | title = Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis. | journal = Am J Surg Pathol | volume = 33 | issue = 8 | pages = 1220-4 | month = Aug | year = 2009 | doi = 10.1097/PAS.0b013e3181a24354 | PMID = 19461510 | PMC = 2716424 }}</ref>


==IHC==
==IHC==
48,460

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