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'''Mantle cell lymphoma''', abbreviated '''MCL''', is less common [[small cell lymphoma]] that is relatively aggressive when compared to other small cell lymphomas. | |||
==General== | |||
*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal | last1 = Hankin | first1 = RC. | last2 = Hunter | first2 = SV. | title = Mantle cell lymphoma. | journal = Arch Pathol Lab Med | volume = 123 | issue = 12 | pages = 1182-8 | month = Dec | year = 1999 | doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 | PMID = 10583923 }}</ref> | |||
==Microscopic== | |||
Features:<ref>Good, D. 17 August 2010.</ref> | |||
*Small monomorphic (uniform size, shape and staining) lymphoid population. | |||
*Abundant mitoses. | |||
*Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages). | |||
*Sclerosed blood vessels. | |||
DDx: | |||
*Other small cell lymphomas, esp. marginal zone lymphoma. | |||
*[[Burkitt's lymphoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Mantle cell lymphoma - low mag.jpg | MCL - low mag. (WC) | |||
Image:Mantle cell lymphoma - intermed mag.jpg | MCL - intermed. mag. (WC) | |||
Image:Mantle cell lymphoma - low mag - cyclin D1.jpg | MCL - low mag. - cyclin D1. (WC) | |||
Image:Mantle cell lymphoma - intermed mag - cyclin D1.jpg | MCL - intermed. mag. - cyclin D1. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)]. | |||
==IHC== | |||
*CD5 +ve. | |||
**Negative in case reports.<ref>URL: [http://path.upmc.edu/cases/case308/dx.html http://path.upmc.edu/cases/case308/dx.html]. Accessed on: 14 January 2012.</ref> | |||
*CD43 +ve. | |||
*Cyclin D1 +ve. | |||
**[[AKA]] BCL1, AKA CCND1.<ref name=omim168461>{{OMIM|168461}}</ref> | |||
Others: | |||
*CD23 -ve. | |||
**Positive in CLL. | |||
==Molecular== | |||
*t(11;14)(q13;q32) / IGH-CCND1.<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> | |||
==See also== | |||
*[[Small cell lymphomas]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Small cell lymphomas]] | |||