Difference between revisions of "Small cell lymphomas"

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Small cell lymphomas (view source)

Revision as of 02:15, 30 December 2013

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→‎Mantle cell lymphoma: split out
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==Mantle cell lymphoma==
==Mantle cell lymphoma==
*Abbreviated ''MCL''.
*Abbreviated ''MCL''.
===General===
{{Main|Mantle cell lymphoma}}
*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal  | last1 = Hankin | first1 = RC. | last2 = Hunter | first2 = SV. | title = Mantle cell lymphoma. | journal = Arch Pathol Lab Med | volume = 123 | issue = 12 | pages = 1182-8 | month = Dec | year = 1999 | doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 | PMID = 10583923 }}</ref>
 
===Microscopic===
Features:<ref>DG. 17 August 2010.</ref>
*Small monomorphic (uniform size, shape and staining) lymphoid population.
*Abundant mitoses.
*Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).
*Sclerosed blood vessels.
 
DDx:
*Other small cell lymphomas, esp. marginal zone lymphoma.
*[[Burkitt's lymphoma]].
 
====Images====
<gallery>
Image:Mantle cell lymphoma - low mag.jpg | MCL - low mag. (WC)
Image:Mantle cell lymphoma - intermed mag.jpg | MCL - intermed. mag. (WC)
Image:Mantle cell lymphoma - low mag - cyclin D1.jpg | MCL - low mag. - cyclin D1. (WC)
Image:Mantle cell lymphoma - intermed mag - cyclin D1.jpg | MCL - intermed. mag. - cyclin D1. (WC)
</gallery>
www:
*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)].
 
===IHC===
*CD5 +ve.
**Negative in case reports.<ref>URL: [http://path.upmc.edu/cases/case308/dx.html http://path.upmc.edu/cases/case308/dx.html]. Accessed on: 14 January 2012.</ref>
*CD43 +ve.
*Cyclin D1 +ve.
**[[AKA]] BCL1, AKA CCND1.<ref name=omim168461>{{OMIM|168461}}</ref>
 
Others:
*CD23 -ve.
**Positive in CLL.
 
===Molecular===
*t(11;14)(q13;q32) / IGH-CCND1.<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>


==Marginal zone lymphoma==
==Marginal zone lymphoma==
Michael
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