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[[Image:Neutrophils.jpg|thumb|right|Neutrophils on a blood film.]] | |||
The '''neutrophil''', [[AKA]] '''polymorphonucleocyte''' or '''PMN''' is a white blood cell. It is often seen in the context of acute inflammation. | The '''neutrophil''', [[AKA]] '''polymorphonucleocyte''' or '''PMN''' is a white blood cell. It is often seen in the context of acute inflammation. | ||
==Histology== | |||
*Little dots = the multilobular nucleus - '''key feature'''. | |||
*Neutrophils are often found with friends, i.e. lymphocytes, plasma cells. | |||
DDx of little dots: | |||
*Nuclear debris - apoptotic cell. | |||
**Apoptotic cell -- has nuclear condensation (pyknosis), eosinophilic cytoplasm. | |||
Notes: | |||
*You find PMNs by their nucleus; on a histologic section don't bother looking for the cell membrane (they are usually impossible to see). | |||
*A collection of PMNs... think about ''[[necrosis]]'' and ''abscess''. | |||
==Pathology== | ==Pathology== | ||
Hypersegmentation = megaloblastic anemia.<ref name=Ref_Klatt63>{{Ref Klatt|63}}</ref> | Hypersegmentation = megaloblastic [[anemia]].<ref name=Ref_Klatt63>{{Ref Klatt|63}}</ref> | ||
==See also== | ==See also== | ||
*[[Basics]]. | *[[Basics]]. | ||
*[[Dysgranulopoiesis]]. | |||
*[[Red blood cell]]. | |||
*[[Chronic granulomatous disease]] - caused by neutrophil dysfunction. | |||
*[[Eosinophil]]. | |||
*[[Auer rods]]. | |||
==References== | ==References== | ||