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Difference between revisions of "Metanephric adenoma"
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'''Metanephric adenoma''' is a benign tumour of the kidney. | |||
It should '''not''' be confused ''[[mesonephric adenoma]]'', another term for ''nephrogenic adenoma''. | |||
This can be remembered as follows ''me'''t'''anephric adenoma is a '''t'''umour''. | |||
==General== | |||
*Benign. | |||
*Afflicts adults and occasionally children. | |||
*May be associated with [[polycythemia]].<ref name=pmid21220212>{{Cite journal | last1 = Le Nué | first1 = R. | last2 = Marcellin | first2 = L. | last3 = Ripepi | first3 = M. | last4 = Henry | first4 = C. | last5 = Kretz | first5 = JM. | last6 = Geiss | first6 = S. | title = Conservative treatment of metanephric adenoma. A case report and review of the literature. | journal = J Pediatr Urol | volume = 7 | issue = 4 | pages = 399-403 | month = Aug | year = 2011 | doi = 10.1016/j.jpurol.2010.09.010 | PMID = 21220212 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref> | |||
*Small uniform cells with: | |||
**Fine chromatin. | |||
**No apparent [[nucleolus]]. | |||
**A relatively smooth nuclear membrane. | |||
*Variable architecture - may be sheets or ductal. | |||
DDx: | |||
*Epithelioid nephroblastoma ([[Wilms tumour]]) - these typically have: | |||
**Irregular nuclear membrane. | |||
**Nucleoli. | |||
**Mitoses (rare in ''metanephric adenoma''). | |||
*[[Papillary renal cell carcinoma|Papillary RCC]].<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Metanephric_adenoma_high_mag.jpg | Metanephric adenoma (WC/Nephron) | |||
Image:Metanephric_adenoma_high_mag_cropped.jpg | Metanephric adenoma - cropped (WC/Nephron) | |||
Image:Metanephric_adenoma_-_intermed_mag.jpg | Metanephric adenoma - PaRCC-like - intermed. mag. (WC/Nephron) | |||
Image:Metanephric_adenoma_-_very_high_mag.jpg | Metanephric adenoma - PaRCC-like - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.nature.com/modpathol/journal/v16/n10/fig_tab/3880886f1.html Metanephric adenoma (nature.com)]. | |||
==IHC== | |||
*WT-1 +ve.<ref name=pmid24083046>{{Cite journal | last1 = Watanabe | first1 = S. | last2 = Naganuma | first2 = H. | last3 = Shimizu | first3 = M. | last4 = Ota | first4 = S. | last5 = Murata | first5 = S. | last6 = Nihei | first6 = N. | last7 = Matsushima | first7 = J. | last8 = Mikami | first8 = S. | last9 = Kuroda | first9 = N. | title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. | journal = Case Rep Pathol | volume = 2013 | issue = | pages = 675875 | month = | year = 2013 | doi = 10.1155/2013/675875 | PMID = 24083046 }}</ref> | |||
*CD57 +ve.<ref name=pmid24083046/> | |||
*AMACR -ve.<ref name=pmid24083046/> | |||
==See also== | |||
*[[Kidney tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Kidney tumours]]. | |||