Difference between revisions of "Dermatologic neoplasms"

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Dermatologic neoplasms (view source)

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→‎Dermal cylindroma: split out
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==Dermal cylindroma==
==Dermal cylindroma==
===General===
{{Main|Dermal cylindroma}}
*Benign skin lesion.
**Occasionally malignant.<ref name=pmid16882695/>
*Should not be confused with ''cylindroma'' ([[adenoid cystic carcinoma]]).
*May be related to ''[[eccrine spiradenoma]]''.<ref name=pmid6302142>{{Cite journal  | last1 = Gerber | first1 = JE. | last2 = Descalzi | first2 = ME. | title = Eccrine spiradenoma and dermal cylindroma. | journal = J Cutan Pathol | volume = 10 | issue = 1 | pages = 73-8 | month = Feb | year = 1983 | doi =  | PMID = 6302142 }}</ref><ref name=pmid8936072>{{Cite journal  | last1 = Lee | first1 = MW. | last2 = Kelly | first2 = JW. | title = Dermal cylindroma and eccrine spiradenoma. | journal = Australas J Dermatol | volume = 37 | issue = 1 | pages = 48-9 | month = Feb | year = 1996 | doi =  | PMID = 8936072 }}</ref>
 
May be familial:<ref name=pmid16882695/>
*Familial cylindromatosis (autosomal dominant).
*Brook–Spiegler syndrome.
 
===Gross===
*Classically scalp - usually head and neck or face.
 
===Microscopic===
Features:<ref name=pmid16882695/>
*Nests of cells that fit together like a jigsaw puzzle - the borders of the nests are opposed and undulate.
*#Basaloid cells with scant cytoplasm and dark nuclei palisade around the edge of the nests.
*#Larger cells with moderate eosinophilic cytoplasm and lighter staining nuclei are at the centre of the nests.
*Cells nests surrounded by a band of hyaline (i.e. glassy, eosinophilic, acellular) material ~ 2X thickness of a basilar cell - '''key feature'''.
**This is basement membrane.
DDx:
*[[Eccrine spiradenoma]].
*[[Basal cell carcinoma]] - has [[myxoid stroma]].
 
====Images====
<gallery>
Image:Dermal_cylindroma_intermed_mag.jpg | Dermal cylindroma. (WC/Nephron)
Image:Dermal_cylindroma_intermed_mag_deep.jpg | Dermal cylindroma - high mag. (WC/Nephron)
</gallery>
www:
*[http://jcp.bmj.com/content/60/2/145/F7.large.jpg Dermal cylindroma (bmj.com)].<ref name=pmid16882695>{{Cite journal  | last1 = Obaidat | first1 = NA. | last2 = Alsaad | first2 = KO. | last3 = Ghazarian | first3 = D. | title = Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. | journal = J Clin Pathol | volume = 60 | issue = 2 | pages = 145-59 | month = Feb | year = 2007 | doi = 10.1136/jcp.2006.041608 | PMID = 16882695 | PMC = 1860616 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860616/?tool=pubmed }}</ref>
 
===Stains===
*PAS +ve (basement membrane).<ref name=pmid16882695/>


==Keratoacanthoma==
==Keratoacanthoma==
Michael
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