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Difference between revisions of "Colorectal adenocarcinoma"
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Colorectal adenocarcinoma (view source)
Revision as of 15:12, 20 December 2013
, 15:12, 20 December 2013→Tumour deposits
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*[[AKA]] ''peritumoral deposits''. | *[[AKA]] ''peritumoral deposits''. | ||
====General==== | ====General==== | ||
Definition - TNM/AJCC 7th edition:<ref name=pmid21555695/> | |||
*Microscopic or macroscopic nodule in the lymphatic drainage of the tumour. | |||
**No standardized distance from tumour criteria are defined.<ref name=pmid24112678>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Hashiguchi | first2 = Y. | last3 = Shimazaki | first3 = H. | last4 = Shinto | first4 = E. | last5 = Kajiwara | first5 = Y. | last6 = Nakanishi | first6 = K. | last7 = Kato | first7 = K. | last8 = Maekawa | first8 = K. | last9 = Nakamura | first9 = T. | title = Peritumoral deposits as an adverse prognostic indicator of colorectal cancer. | journal = Am J Surg | volume = | issue = | pages = | month = Oct | year = 2013 | doi = 10.1016/j.amjsurg.2013.04.009 | PMID = 24112678 }}</ref> | |||
*No findings suggestive of it being a lymph node replaced by tumour: | |||
*#No significant lymphoid tissue. | |||
*#Irregular contour. | |||
*#*Round nodules of tumour are considered lymph nodes that are replaced by tumour. | |||
Significance: | |||
*Poor prognosticator. | *Poor prognosticator. | ||
**Can be understood as a type of invasive front/border, e.g. ''well-circumscribed border'' versus ''infiltrative border''.<ref name=pmid24112678/> | **Can be understood as a type of invasive front/border, e.g. ''well-circumscribed border'' versus ''infiltrative border''.<ref name=pmid24112678/> | ||
* | |||
*Tumour | Staging implications: | ||
*Generally, tumour deposits are '''not''' counted as (positive) lymph nodes.<ref name=pmid21555695>{{Cite journal | last1 = Nagtegaal | first1 = ID. | last2 = Tot | first2 = T. | last3 = Jayne | first3 = DG. | last4 = McShane | first4 = P. | last5 = Nihlberg | first5 = A. | last6 = Marshall | first6 = HC. | last7 = Påhlman | first7 = L. | last8 = Brown | first8 = JM. | last9 = Guillou | first9 = PJ. | title = Lymph nodes, tumor deposits, and TNM: are we getting better? | journal = J Clin Oncol | volume = 29 | issue = 18 | pages = 2487-92 | month = Jun | year = 2011 | doi = 10.1200/JCO.2011.34.6429 | PMID = 21555695 }}</ref> | |||
**If no positive lymph nodes are present the N stage is pN1c. | |||
*Tumour stage is ''not'' affected by tumour deposits.<ref name=pmid21555695/> | |||
Note: | |||
*The definition of ''tumour deposit'' has changed significantly between the TMN/AJCC fifth, sixth and seventh editions.<ref name=pmid21555695/> | |||
=====Ueno criteria===== | =====Ueno criteria===== | ||