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| ==Melanoma== | | ==Melanoma== |
| {{Main|Malignant melanoma}} | | {{Main|Malignant melanoma}} |
| ===General===
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| *Known as the great mimicker in pathology; it may look like many things. | | *Known as the great mimicker in pathology; it may look like many things. |
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| ===Microscopic===
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| Features:
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| *Classic appearance of melanoma:
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| **Loosely cohesive; mix of small nests of cells, single cells.
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| **Usu. mixed of spindle and ovoid cell morphology.
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| **+/-Occasional large binucleated cells.
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| **+/-Cytoplasm: brown pigment (melanin).
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| **+/-Prominent (large) red nucleoli (like in ''serous carcinoma'' of the ovary).
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| **Often marked nuclear pleomorphism - variation in cell size, shape & staining (like in ''serous carcinoma'' of the ovary).
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| **[[Nuclear pseudoinclusions]] (like in ''papillary thyroid carcinoma'').
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| =Less common malignant= | | =Less common malignant= |