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Difference between revisions of "Cat scratch disease"
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'''Cat scratch disease''', also '''cat scratch fever''', is an uncommon [[lymph node pathology|pathology of the lymph node]]. | |||
==General== | |||
*Infection caused ''[[Bartonella henselae]]'',<ref name=pmid19332922>{{Cite journal | last1 = Jerris | first1 = RC. | last2 = Regnery | first2 = RL. | title = Will the real agent of cat-scratch disease please stand up? | journal = Annu Rev Microbiol | volume = 50 | issue = | pages = 707-25 | month = | year = 1996 | doi = 10.1146/annurev.micro.50.1.707 | PMID = 8905096 }}</ref> a gram-negative bacilla (0.3-1.0 x 0.6-3.0 micrometers) in chains, clumps, or singular.<ref name=Ref_ILNP110>{{Ref ILNP|110}}</ref> | |||
*Treatment: antibiotics. | |||
==Clinical== | |||
Features:<ref name=Ref_ILNP113>{{Ref ILNP|113}}</ref> | |||
*Usually unilateral. | |||
**May be disseminated in individuals with immune dysfunction. | |||
*Contact with cats. | |||
==Micrograph== | |||
Features:<ref name=Ref_ILNP113>{{Ref ILNP|113}}</ref> | |||
*Necrotizing granulomas with: | |||
**Neutrophils present in microabscess (necrotic debris) - '''key feature'''. | |||
***Microabscesses often described as "stellate" (star-shaped). | |||
*+/-Multinucleated giant cells. | |||
Notes: | |||
*May involve capsule or perinodal tissue. | |||
DDx of stellate abscess in lymph nodes - ''cat split'':<ref name=pmid>URL: [http://www.dermpathmd.com/mnemonics/mnemonics_dermatopathology.htm http://www.dermpathmd.com/mnemonics/mnemonics_dermatopathology.htm]. Accessed on: 23 September 2011.</ref> | |||
*Cat-scratch disease. | |||
*[[Sporotrichosis]]. | |||
*[[Lymphogranuloma venereum]]. | |||
*[[Tularemia]]. | |||
===Images=== | |||
www: | |||
*[http://www.webpathology.com/image.asp?case=386&n=1 Cat-scratch disease (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=2&Case=386 Cat-scratch disease - high mag. (webpathology.com)] | |||
<gallery> | |||
Image:Cat_scratch_disease_-_very_low_mag.jpg | CSD - very low mag. - showing serpentine shaped microabscesses (WC) | |||
Image:Cat_scratch_disease_-_low_mag.jpg | CSD - low mag. - showing serpentine shaped microabscesses (WC) | |||
Image:Cat_scratch_disease_-b-_high_mag.jpg | CSD - high mag. - showing neutrophilic abscesses (WC) | |||
</gallery> | |||
==Stains== | |||
*Warthin-Starry stain +ve. | |||
==IHC== | |||
*B. henselae IHC stain +ve - '''diagnostic'''. | |||
==See also== | |||
*[[Lymph node pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Lymph node pathology]] | |||