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Difference between revisions of "Palmar fibromatosis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Palmar fibromatosis -- high mag.jpg | |||
| Width = | |||
| Caption = Palmar fibromatosis. [[H&E stain]]. | |||
| Micro = poorly demarcated, usu. multiple lesions/multiple nodules, composed of bland spindle cells in dense collagen; spindle cells have pale grey cytoplasm and a pale ovoid nuclei with small round nucleolus, +/-giant cells (rare) | |||
| Subtypes = | |||
| LMDDx = [[calcifying aponeurotic fibroma]], extra-abdominal desmoid [[fibromatosis]], inclusion body [[fibromatosis]], [[fibrosarcoma]], [[synovial sarcoma]], [[epithelioid sarcoma]], [[metastasis|Metastatic]] metaplastic carcinoma | |||
| Stains = | |||
| IHC = beta-catenin +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = hand - palmar fascia, classically ring finger | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = male > female, +/-family history | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Palmar fibromatosis''', also '''Dupuytren's contracture''' and '''Dupuytren disease''', is a common pathology of the hand. | '''Palmar fibromatosis''', also '''Dupuytren's contracture''' and '''Dupuytren disease''', is a common pathology of the hand. | ||
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===Image=== | ===Image=== | ||
<gallery> | |||
Image:Morbus_dupuytren_fcm.jpg Palmar fibromatosis. (WC) | |||
</gallery> | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref>URL: [http://surgpathcriteria.stanford.edu/softfib/plantar_fibromatosis/printable.html http://surgpathcriteria.stanford.edu/softfib/plantar_fibromatosis/printable.html]. Accessed on: 6 January 2011.</ref><ref name=standford_pf_ddx>URL: [http://surgpathcriteria.stanford.edu/softfib/palmar_fibromatosis/differentialdiagnosis.html http://surgpathcriteria.stanford.edu/softfib/palmar_fibromatosis/differentialdiagnosis.html]. Accessed on: 9 November 2012.</ref> | Features:<ref>URL: [http://surgpathcriteria.stanford.edu/softfib/plantar_fibromatosis/printable.html http://surgpathcriteria.stanford.edu/softfib/plantar_fibromatosis/printable.html]. Accessed on: 6 January 2011.</ref><ref name=standford_pf_ddx>URL: [http://surgpathcriteria.stanford.edu/softfib/palmar_fibromatosis/differentialdiagnosis.html http://surgpathcriteria.stanford.edu/softfib/palmar_fibromatosis/differentialdiagnosis.html]. Accessed on: 9 November 2012.</ref> | ||
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*[[metastasis|Metastatic]] metaplastic carcinoma, e.g. [[metaplastic breast carcinoma]] - extremely uncommon. | *[[metastasis|Metastatic]] metaplastic carcinoma, e.g. [[metaplastic breast carcinoma]] - extremely uncommon. | ||
Images: | ===Images=== | ||
<gallery> | |||
Image: Palmar fibromatosis -- intermed mag.jpg | PF - intermed. mag. | |||
Image: Palmar fibromatosis -- high mag.jpg | PF - high mag. | |||
Image: Palmar fibromatosis - alt -- high mag.jpg | PF - high mag. | |||
Image: Palmar fibromatosis -- very high mag.jpg | PF - very high mag. | |||
</gallery> | |||
www: | |||
*[http://www.biomedsearch.com/attachments/display/00/16/69/68/16696857/1479-5876-4-21-2.jpg Palmer fibromatosis (biomedsearch.com)].<ref name=pmid16696857>{{cite journal |author=Wang L, Zhu H |title=Clonal analysis of palmar fibromatosis: a study whether palmar fibromatosis is a real tumor |journal=J Transl Med |volume=4 |issue= |pages=21 |year=2006 |pmid=16696857 |pmc=1488873 |doi=10.1186/1479-5876-4-21 |url=http://www.biomedsearch.com/nih/Clonal-analysis-palmar-fibromatosis-study/16696857.html}}</ref> | *[http://www.biomedsearch.com/attachments/display/00/16/69/68/16696857/1479-5876-4-21-2.jpg Palmer fibromatosis (biomedsearch.com)].<ref name=pmid16696857>{{cite journal |author=Wang L, Zhu H |title=Clonal analysis of palmar fibromatosis: a study whether palmar fibromatosis is a real tumor |journal=J Transl Med |volume=4 |issue= |pages=21 |year=2006 |pmid=16696857 |pmc=1488873 |doi=10.1186/1479-5876-4-21 |url=http://www.biomedsearch.com/nih/Clonal-analysis-palmar-fibromatosis-study/16696857.html}}</ref> | ||
*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=8235 Palmar fibromatosis (unibas.ch)]. | *[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=8235 Palmar fibromatosis (unibas.ch)]. | ||