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#redirect [[Colon#Ischemic_colitis]]
'''Ischemic colitis''' is inflammation of the [[colon]] due to a compromised blood supply.
 
It is also known as '''colonic ischemia''' and '''ischemia of the colon'''.
==General==
*May occur together with ''[[ischemic enteritis]]'', in which case it is known as ''ischemic enterocolitis''.
 
Etiology - anything that leads to vascular occlusion:
*[[Atherosclerosis]].
*[[Vasculitis]].
*Embolization, e.g. thrombotic, foreign body.
 
Possible associated pathology:
*[[Necrotizing enteritis]] - necrosis of the small bowel only.
*[[Necrotizing enterocolitis]] - necrosis of the small and large bowel.
 
Closely related:
*[[Radiation colitis]].
*[[Infectious colitis]].
 
Note:
*Ischemia = compromised blood supply.
 
==Gross==
Features - location:<ref name=Ref_PBoD852>{{Ref PBoD|852}}</ref>
*Luminal part (mucosa & submucosa) affected - edema.
*Splenic flexture of colon commonly affected (vascular watershed).
 
Note:
*May have pseudomembranes (classically assoc. with ''C. difficile'' colitis), i.e. mimics an infectious process.
*DDx for pseudomembranes:<ref name=Ref_PBoD837-8>{{Ref PBoD|837-8}}</ref>
**[[C. difficile]] induced pseudomembranous colitis.
**Ischemic colitis.
**Volvulus.
**Necrotizing infections.
**... anything that causes severe mucosal injury.
*Radiologic correlate = bowel wall thickening.
 
==Microscopic==
Features:
*Withering crypts - '''important'''.
**Colonic epithelium has decreased cytoplasm - NC ratio increased.
**Usually with decreased goblet cells.
*Crypt loss/drop-out.
**Less intestinal crypts present.
*Lamina propria hyalinization.
**Dense pink material replaces loose connective tissue.
*Submucosa hyalinization.
*+/-Pseudomembranes (microscopic):<ref name=Ref_PBoD837-8>{{Ref PBoD|837-8}}</ref>
**Loss of surface epithelium.
**[[PMN]]s in lamina propria.
**+/-Capillary fibrin thrombi.
 
Note:
*Pseudomembranes arise from the crypts - considered ''acute''.
 
DDx:
*[[Inflammatory bowel disease]].
*[[Radiation colitis]].
*Toxins/drugs.
**Rosuvastatin.<ref name=pmid22744258>{{Cite journal  | last1 = Tan | first1 = J. | last2 = Pretorius | first2 = CF. | last3 = Flanagan | first3 = PV. | last4 = Pais | first4 = A. | title = Adverse drug reaction: rosuvastatin as a cause for ischaemic colitis in a 64-year-old woman. | journal = BMJ Case Rep | volume = 2012 | issue =  | pages =  | month =  | year = 2012 | doi = 10.1136/bcr.11.2011.5270 | PMID = 22744258 }}</ref>
**[[Cocaine]].<ref name=pmid21237534>{{Cite journal  | last1 = Fabra | first1 = I. | last2 = Roig | first2 = JV. | last3 = Sancho | first3 = C. | last4 = Mir-Labrador | first4 = J. | last5 = Sempere | first5 = J. | last6 = García-Ferrer | first6 = L. | title = [Cocaine-induced ischemic colitis in a high-risk patient treated conservatively]. | journal = Gastroenterol Hepatol | volume = 34 | issue = 1 | pages = 20-3 | month = Jan | year = 2011 | doi = 10.1016/j.gastrohep.2010.10.005 | PMID = 21237534 }}</ref>
**[[NSAID]] overdose.<ref name=pmid11736840>{{Cite journal  | last1 = Appu | first1 = S. | last2 = Thompson | first2 = G. | title = Gangrenous ischaemic colitis following non-steroidal anti-inflammatory drug overdose. | journal = ANZ J Surg | volume = 71 | issue = 11 | pages = 694-5 | month = Nov | year = 2001 | doi =  | PMID = 11736840 }}</ref>
*[[Infectious colitis]].
 
===Images===
<gallery>
Image:Ischemic_colitis_-_low_mag.jpg | Ischemic colitis - low mag. (WC/Nephron)
Image:Ischemic_colitis_-_high_mag.jpg | Ischemic colitis - high mag. (WC/Nephron)
Image:Ischemic_colitis_-_very_high_mag.jpg | Ischemic colitis - very high mag. (WC/Nephron)
Image:Colonic_pseudomembranes_low_mag.jpg | Colonic pseudomembranes - low mag. (WC/Nephron)
Image:Colonic_pseudomembranes_intermed_mag.jpg | Colonic pseudomembranes - intermed. mag. (WC/Nephron)
</gallery>
www:
*[http://www.flickr.com/photos/euthman/3385570758/ Ischemic colitis (flickr.com/euthman)].
*[http://esynopsis.uchc.edu/eAtlas/GI/1018b.htm Ischemic colitis (uchc.edu)].
 
==Sign out==
===Biopsy===
<pre>
TRANSVERSE COLON, BIOPSY:
- SEVERE ACTIVE COLITIS WITH ATTENUATED EPITHELIAL CYTOPLASM AND ULCERATION.
- CELLULAR DEBRIS.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
 
COMMENT:
The attenuated cytoplasm is compatible with ischemia; however, it is not
accompanied with other suggestive findings (crypt drop out, lamina propria
fibrosis, pseudomembranes).  The crypt architecture is test tube-like.
 
The differential diagnosis includes: ischemia, drug reaction, infectious
etiologies and, less likely, inflammatory bowel disease. Clinical
correlation is required.
</pre>
 
<pre>
COLON, SPLENIC FLEXURE, BIOPSY:
- PATCHY MODERATE ACTIVE COLITIS WITH ATTENUATED EPITHELIAL CYTOPLASM,
  FOCALLY DECREASED GOBLET CELLS AND ULCERATION.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
 
COMMENT:
The findings are consistent with ischemia; however, they are not diagnostic.
 
The differential diagnosis includes: ischemia, drug reaction, infectious
etiologies and, less likely, inflammatory bowel disease. Clinical
correlation is required.
</pre>
 
===Short version===
<pre>
LEFT COLON AND SIGMOID COLON, RESECTION:
- PSEUDOMEMBRANOUS COLITIS, SEE COMMENT.
- ONE LYMPH NODE NEGATIVE FOR MALIGNANCY ( 0 POSITIVE / 1 ).
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
 
COMMENT:
Pseudomembrane formation is a non-specific finding.  It is consistent with ischemia;
however, it may be seen in other contexts, including infection. Clinical correlation is
required.
</pre>
 
===Long version===
<pre>
RECTOSIGMOID, RESECTION:
- BOWEL WALL ISCHEMIA WITH PERFORATION, SEROSITIS, MICROABSCESS FORMATION AND FOCAL
POORLY FORMED PSEUDOMEMBRANES.
- NEGATIVE FOR MALIGNANCY.
- PLEASE SEE COMMENT.
 
COMMENT:
There is no evidence of inflammatory bowel disease:
The unaffected mucosa does not have obvious architectural distortion. No granulomas are
identified. The inflammation is largely associated with necrosis/ischemic changes
and favoured to be reactive.
 
The poorly formed pseudomembranes are associated with mural ischemic changes; they do not
specifically suggest an infection in this context.
 
The blood vessels do not show a vasculitis, or significant atherosclerosis.  Thrombi are
seen on several sections and found predominantly in the (smaller) veins.
 
Considerations are thrombosis, thromboembolism, mechanical vascular compromise, and
infectious etiologies.  A vascular compromise is favoured as the underlying cause.
 
Clinical and radiologic correlation is suggested.
</pre>
 
===Another long version===
<pre>
SIGMOID COLON, RESECTION:
- BOWEL WALL ISCHEMIA WITH PERFORATION, SEROSITIS, AND FOCAL POORLY FORMED
PSEUDOMEMBRANES.
- MILD ATHEROSCLEROSIS.
- DIVERTICULAR DISEASE.
- TWO LYMPH NODES NEGATIVE FOR MALIGNANCY ( 0 POSITIVE / 2 ).
- PLEASE SEE COMMENT.
 
COMMENT:
The sections show the changes of acute and chronic ischemic colitis (submucosal fibrosis,
lamina propria hyalinization, focal crypt drop-out, decreased goblet cells, pigmented
macrophages in the lamina propria, intraepithelial neutrophils).
 
No granulomas are identified. The inflammation is largely associated with
the necrosis/ischemic changes and favoured to be reactive.
 
The poorly formed pseudomembranes are associated with mural ischemic changes; they do not
specifically suggest an infectious etiology in this context.
 
The blood vessels do not show a vasculitis. However, focal neutrophilic perivascular
inflammation is seen; this is probably a reactive process. No vascular thrombi are
identified.
 
The findings are compatible with perforation secondary to a foreign body in the setting of
chronic ischemia.
</pre>
 
===Micro===
====Negative for ischemic colitis====
The sections show colorectal mucosa with preservation of the crypt density and
epithelium with a normal nuclear-to-cytoplasm ratio. There is no apparent lamina propria
hyalinization.  The muscularis mucosa is prominent.  Focally, lymphoid aggregates are
present.
 
No cryptitis is present.  Neutrophils are not apparent in the lamina propria. No erosions
are identified.
 
The epithelium matures appropriately from the crypt base to the surface.
 
==See also==
*[[Infarction]].
*[[Colon]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
Michael
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