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Dermatopathic lymphadenopathy (view source)
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'''Dermatopathic lymphadenopathy''' is a rare [[lymph node pathology|pathology of the lymph nodes]]. | |||
==General== | |||
*Lymphadenopathy associated with a skin lesion - '''key feature'''. | |||
*May be benign ''or'' malignant (e.g. T-cell lymphoma). | |||
==Microscopic== | |||
Features:<ref name=ILNP226>{{Ref ILNP|226}}</ref> | |||
*Abundant histiocytes & special histiocytes - in loose irregular clusters - located in the sinuses, i.e. sinus histiocytosis - '''key feature''': | |||
**Do ''not'' form granuloma; may be similar to ''toxoplasma''. | |||
*Plasma cells (medulla). | |||
*Eosinophils. | |||
Histiocytes & special histiocytes: | |||
*Histiocytes: | |||
**+/-Melanin pigment '''key feature''' (if present). | |||
**Lipid-laden macrophages. | |||
*Interdigitating dendritic cells: | |||
**Need IHC to identify definitively. | |||
*Langerhans cells: | |||
**Classically have a kidney bean nuclei. | |||
**Need IHC to identify definitively. | |||
DDx: | |||
*[[Metastatic]] [[malignant melanoma]] - (melanin) pigmented cells have nuclear atypia, not histiocytes. | |||
*[[Sinus histiocytosis]] - no cells with melanin. | |||
===Images=== | |||
<gallery> | |||
Image:Dermatopathic_lymphadenopathy_-_very_low_mag.jpg | DL - very low mag. (WC) | |||
Image:Dermatopathic_lymphadenopathy_-_low_mag.jpg | DL - low mag. (WC) | |||
Image:Dermatopathic_lymphadenopathy_-_intermed_mag.jpg | DL - intermed. mag. (WC) | |||
Image:Dermatopathic_lymphadenopathy_-_high_mag.jpg | DL - high mag. (WC) | |||
Image:Dermatopathic_lymphadenopathy_-_very_high_mag.jpg | DL - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
*Interdigitating dendritic cells: S100 +ve, CD1a -ve. | |||
*Langerhans cells: S100 +ve, CD1a +ve. | |||
==See also== | |||
*[[Lymph node pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Lymph node pathology]] | |||