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Difference between revisions of "Prostate gland"
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→High-grade prostatic intraepithelial neoplasia
| Line 430: | Line 430: | ||
**''PIN'' not otherwise specified refers to ''HGPIN''. | **''PIN'' not otherwise specified refers to ''HGPIN''. | ||
**Low-grade PIN has the architecture of HGPIN but lacks the nuclear atypia. | **Low-grade PIN has the architecture of HGPIN but lacks the nuclear atypia. | ||
Prostate cancer on follow-up biopsy by number of HGPIN sites from Merrimen ''et al.'':<ref name=pmid19524976>{{Cite journal | last1 = Merrimen | first1 = JL. | last2 = Jones | first2 = G. | last3 = Walker | first3 = D. | last4 = Leung | first4 = CS. | last5 = Kapusta | first5 = LR. | last6 = Srigley | first6 = JR. | title = Multifocal high grade prostatic intraepithelial neoplasia is a significant risk factor for prostatic adenocarcinoma. | journal = J Urol | volume = 182 | issue = 2 | pages = 485-90; discussion 490 | month = Aug | year = 2009 | doi = 10.1016/j.juro.2009.04.016 | PMID = 19524976 }}</ref> | |||
{| class="wikitable sortable" | |||
! Number of cores<br> with HGPIN | |||
! Odds ratio of cancer<br> on follow-up (95% CI) | |||
|- | |||
| 0 | |||
| 1.00 (reference) | |||
|- | |||
| 1 | |||
| 1.02 (0.73-1.40) | |||
|- | |||
| 2 | |||
| 1.55 (1.08-2.21) | |||
|- | |||
| 3 | |||
| 1.99 (1.16-3.40) | |||
|- | |||
| 4 | |||
| 2.66 (1.10-6.40) | |||
|} | |||
===Microscopic=== | ===Microscopic=== | ||