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Difference between revisions of "Rosai-Dorfman disease"
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| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = nodules (skin) | ||
| Grossing = | | Grossing = | ||
| Site = [[lymph node]]s - see ''[[lymph node pathology]]'' | | Site = [[skin]], [[lymph node]]s - see ''[[lymph node pathology]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = fever, lymphadenopathy | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = leukocytosis with neurophilia | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = usually self-limited, benign | ||
| Other = | | Other = | ||
| ClinDDx = }} | | ClinDDx = lymphoma, infections with lymphadenopathy }} | ||
'''Rosai-Dorfman disease''', abbreviated '''RDD''', is a rare [[lymph node pathology]]. | '''Rosai-Dorfman disease''', abbreviated '''RDD''', is a rare [[lymph node pathology]]. | ||
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==General== | ==General== | ||
*Super rare. | *Super rare. | ||
*Prognosis - good.<ref name=pmid23739703/> | *Prognosis - good, usually self-limited.<ref name=pmid23739703/> | ||
Clinical findings:<ref name=pmid19668942>{{Cite journal | last1 = Landim | first1 = FM. | last2 = Rios | first2 = Hde O. | last3 = Costa | first3 = CO. | last4 = Feitosa | first4 = RG. | last5 = Rocha Filho | first5 = FD. | last6 = Costa | first6 = AA. | title = Cutaneous Rosai-Dorfman disease. | journal = An Bras Dermatol | volume = 84 | issue = 3 | pages = 275-8 | month = Jul | year = 2009 | doi = | PMID = 19668942 }}</ref><ref name=pmid23739703>{{Cite journal | last1 = Leal | first1 = PA. | last2 = Adriano | first2 = AL. | last3 = Breckenfeld | first3 = MP. | last4 = Costa | first4 = IS. | last5 = de Sousa | first5 = AR. | last6 = Gonçalves | first6 = Hde S. | title = Rosai-Dorfman disease presenting with extensive cutaneous manifestation - case report. | journal = An Bras Dermatol | volume = 88 | issue = 2 | pages = 256-9 | month = | year = | doi = 10.1590/S0365-05962013000200014 | PMID = 23739703 }}</ref> | Clinical findings:<ref name=pmid19668942>{{Cite journal | last1 = Landim | first1 = FM. | last2 = Rios | first2 = Hde O. | last3 = Costa | first3 = CO. | last4 = Feitosa | first4 = RG. | last5 = Rocha Filho | first5 = FD. | last6 = Costa | first6 = AA. | title = Cutaneous Rosai-Dorfman disease. | journal = An Bras Dermatol | volume = 84 | issue = 3 | pages = 275-8 | month = Jul | year = 2009 | doi = | PMID = 19668942 }}</ref><ref name=pmid23739703>{{Cite journal | last1 = Leal | first1 = PA. | last2 = Adriano | first2 = AL. | last3 = Breckenfeld | first3 = MP. | last4 = Costa | first4 = IS. | last5 = de Sousa | first5 = AR. | last6 = Gonçalves | first6 = Hde S. | title = Rosai-Dorfman disease presenting with extensive cutaneous manifestation - case report. | journal = An Bras Dermatol | volume = 88 | issue = 2 | pages = 256-9 | month = | year = | doi = 10.1590/S0365-05962013000200014 | PMID = 23739703 }}</ref> | ||
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*Leukocytosis with neutrophilia. | *Leukocytosis with neutrophilia. | ||
*Polyclonal gammaglobulinemia. | *Polyclonal gammaglobulinemia. | ||
==Gross== | |||
*Skin: nodules.<ref name=pmid23739703/> | |||
==Microscopic== | ==Microscopic== | ||