Difference between revisions of "Epidermal inclusion cyst"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Micro      = cyst lining by a stratified squamous epithelium with a granular layer - contains keratin, +/-[[granuloma|Granulomatous inflammation]] due to rupture, no significant nuclear atypia
| Subtypes  =
| LMDDx      = [[pilar cyst]], [[eccrine hidrocystoma]] (eyelid), [[dermoid cyst]], cystic [[squamous cell carcinoma of the skin|squamous cell carcinoma]], [[keratoacanthoma]], [[dermatofibrosarcoma protuberans]], hybrid epidermoid and trichilemmal cyst
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = nodule +/-yellow colour
| Grossing  =
| Site      = [[skin]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = other [[skin cysts]]
}}
'''Epidermal inclusion cyst''', abbreviated '''EIC''', is a very common [[skin]] pathology. It is also know as '''epidermal cyst''', '''epidermoid cyst''',<ref name=Ref_Derm302>{{Ref Derm|302}}</ref> and '''follicular cyst, infundibular type'''.
'''Epidermal inclusion cyst''', abbreviated '''EIC''', is a very common [[skin]] pathology. It is also know as '''epidermal cyst''', '''epidermoid cyst''',<ref name=Ref_Derm302>{{Ref Derm|302}}</ref> and '''follicular cyst, infundibular type'''.


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===Microscopic===
===Microscopic===
Features:
Features:
*Cyst lining has a granular layer - '''key feature'''.<ref>URL: [http://emedicine.medscape.com/article/1058907-diagnosis http://emedicine.medscape.com/article/1058907-diagnosis]. Accessed on: 18 March 2011.</ref>  
*Cyst lining by a stratified squamous epithelium with a granular layer - '''key feature'''.<ref>URL: [http://emedicine.medscape.com/article/1058907-diagnosis http://emedicine.medscape.com/article/1058907-diagnosis]. Accessed on: 18 March 2011.</ref>  
*Trapped collagen bundles at edge of lesion with surrounded by fibroblasts.
**No significant nuclear atypia.
*Keratin.
**Contains keratin - acellular, lamellar appearance.
*+/-[[granuloma|Granulomatous inflammation]] due to rupture.
*+/-[[granuloma|Granulomatous inflammation]] due to rupture.


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