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Difference between revisions of "Sarcoidosis"
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| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = fungal infection, [[tuberculosis]], other infections, drug reactions | ||
| Stains = | | Stains = AFB -ve, GMS -ve, PASD -ve | ||
| IHC = | | IHC = | ||
| EM = | | EM = | ||
| Line 14: | Line 14: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = hilar lymph nodes | | Site = [[lung]], hilar lymph nodes of the lung, other sites | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 22: | Line 22: | ||
| Prevalence = uncommon | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = bilateral hilar lymphadenopathy | | Rads = +/-bilateral hilar lymphadenopathy (very common), +/-interstitial pattern, +/- pulmonary infiltrates, +/-cystic/bullous changes | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = | ||
| Other = | | Other = flow cytometry to r/o lymphoma | ||
| ClinDDx = | | ClinDDx = [[lymphoma]], [[metastatic carcinoma]], [[Wegener's granulomatosis]], others | ||
}} | }} | ||
'''Sarcoidosis''' is non-necrotizing granulomatous disease of unknown etiology. It classically associated with (pulmonary) hilar lymphadenopathy. It may be found in almost any organ, e.g. [[heart]], [[appendix]]. | '''Sarcoidosis''' is non-necrotizing [[granulomatous disease]] of unknown etiology. It classically associated with (pulmonary) hilar lymphadenopathy. It may be found in almost any organ, e.g. [[heart]], [[appendix]]. | ||
==General== | ==General== | ||
| Line 35: | Line 35: | ||
==Gross== | ==Gross== | ||
*Bilateral lymphadenopathy | *Lungs - classic location.<ref name=pmid23597964>{{Cite journal | last1 = Rao | first1 = DA. | last2 = Dellaripa | first2 = PF. | title = Extrapulmonary manifestations of sarcoidosis. | journal = Rheum Dis Clin North Am | volume = 39 | issue = 2 | pages = 277-97 | month = May | year = 2013 | doi = 10.1016/j.rdc.2013.02.007 | PMID = 23597964 }} | ||
</ref> | |||
*Bilateral hilar lymphadenopathy. | |||
DDx (radiologic): | |||
* | *Carcinomatosis - interstitial pattern.<ref>URL: [http://www.radiologyassistant.nl/en/46b480a6e4bdc http://www.radiologyassistant.nl/en/46b480a6e4bdc]. Accessed on: 23 May 2010.</ref> | ||
*Lymphoma - bilateral lymphadenopathy +/- mediastinal lymphadenopathy.<ref name=pmid23207258>{{Cite journal | last1 = Boujaoude | first1 = Z. | last2 = Dahdel | first2 = M. | last3 = Pratter | first3 = M. | last4 = Kass | first4 = J. | title = Endobronchial ultrasound with transbronchial needle aspiration in the diagnosis of bilateral hilar and mediastinal lymphadenopathy. | journal = J Bronchology Interv Pulmonol | volume = 19 | issue = 1 | pages = 19-23 | month = Jan | year = 2012 | doi = 10.1097/LBR.0b013e3182442b89 | PMID = 23207258 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||