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Difference between revisions of "Leydig cell tumour"
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| Symptoms = | | Symptoms = | ||
| Prevalence = uncommon | | Prevalence = uncommon | ||
| Bloodwork = +/-elevated testosterone | | Bloodwork = +/-elevated testosterone (rarely elevated estradiol) | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = usu. benign | ||
| Other = | | Other = | ||
| ClinDDx = other testicular tumours | | ClinDDx = other testicular tumours | ||
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*Arises from the interstitial cell. | *Arises from the interstitial cell. | ||
*May be associated with increased testosterone. | *May be associated with increased testosterone. | ||
*Can be malignant in adults.<ref name=pmid17284120>{{Cite journal | last1 = Al-Agha | first1 = OM. | last2 = Axiotis | first2 = CA. | title = An in-depth look at Leydig cell tumor of the testis. | journal = Arch Pathol Lab Med | volume = 131 | issue = 2 | pages = 311-7 | month = Feb | year = 2007 | doi = 10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2 | PMID = 17284120 | URL = http://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282007%29131%5B311:AILALC%5D2.0.CO;2 }}</ref> | |||
Clinical:<ref name=pmid17284120/> | |||
*+/-Elevated testosterone. | |||
**Rarely elevated estradiol. | |||
*ACTH low. | |||
==Gross== | ==Gross== | ||
*Solid, lobulated. | *Solid, lobulated. | ||
*Red/tan. | *Red/tan. | ||
*Typically 3-5 cm.<ref name=pmid17284120/> | |||
Image: | Image: | ||
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*Vacuolization (cytoplasm) - '''key feature'''. | *Vacuolization (cytoplasm) - '''key feature'''. | ||
*Cytoplasm - clear to eosinophilic - '''important'''. | *Cytoplasm - clear to eosinophilic - '''important'''. | ||
**Usually eosinophilic. | |||
*''Reinke crystals'' - classic finding, usually not present. | *''Reinke crystals'' - classic finding, usually not present. | ||
**Cylindrical crystalloid eosinophilic cytoplasmic bodies. | **Cylindrical crystalloid eosinophilic cytoplasmic bodies. | ||
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*[[Spermatocytic seminoma]] - may have eosinophilic cytoplasm. | *[[Spermatocytic seminoma]] - may have eosinophilic cytoplasm. | ||
*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies. | *[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies. | ||
*Leydig cell hyperplasia. | |||
*[[Granular cell tumour]].<ref name=pmid17284120/> | |||
===Images=== | ===Images=== | ||