Difference between revisions of "Leydig cell tumour"

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| Symptoms  =
| Symptoms  =
| Prevalence = uncommon
| Prevalence = uncommon
| Bloodwork  = +/-elevated testosterone
| Bloodwork  = +/-elevated testosterone (rarely elevated estradiol)
| Rads      =
| Rads      =
| Endoscopy  =
| Endoscopy  =
| Prognosis  = benign
| Prognosis  = usu. benign
| Other      =
| Other      =
| ClinDDx    = other testicular tumours
| ClinDDx    = other testicular tumours
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*Arises from the interstitial cell.
*Arises from the interstitial cell.
*May be associated with increased testosterone.
*May be associated with increased testosterone.
*Can be malignant in adults.<ref name=pmid17284120>{{Cite journal  | last1 = Al-Agha | first1 = OM. | last2 = Axiotis | first2 = CA. | title = An in-depth look at Leydig cell tumor of the testis. | journal = Arch Pathol Lab Med | volume = 131 | issue = 2 | pages = 311-7 | month = Feb | year = 2007 | doi = 10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2 | PMID = 17284120 | URL = http://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282007%29131%5B311:AILALC%5D2.0.CO;2 }}</ref>


Clinical:<ref name=pmid17284120/>
*+/-Elevated testosterone.
**Rarely elevated estradiol.
*ACTH low.
==Gross==
==Gross==
*Solid, lobulated.
*Solid, lobulated.
*Red/tan.
*Red/tan.
*Typically 3-5 cm.<ref name=pmid17284120/>


Image:
Image:
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*Vacuolization (cytoplasm) - '''key feature'''.
*Vacuolization (cytoplasm) - '''key feature'''.
*Cytoplasm - clear to eosinophilic - '''important'''.
*Cytoplasm - clear to eosinophilic - '''important'''.
**Usually eosinophilic.
*''Reinke crystals'' - classic finding, usually not present.
*''Reinke crystals'' - classic finding, usually not present.
**Cylindrical crystalloid eosinophilic cytoplasmic bodies.
**Cylindrical crystalloid eosinophilic cytoplasmic bodies.
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*[[Spermatocytic seminoma]] - may have eosinophilic cytoplasm.
*[[Spermatocytic seminoma]] - may have eosinophilic cytoplasm.
*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies.
*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies.
*Leydig cell hyperplasia.
*[[Granular cell tumour]].<ref name=pmid17284120/>


===Images===
===Images===
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