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→‎Leydig cell tumour: split-out
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==Leydig cell tumour==
==Leydig cell tumour==
*[[AKA]] ''interstitial cell tumour''.
*[[AKA]] ''interstitial cell tumour''.
 
{{Main|Leydig cell tumour}}
===General===
*Arises from interstitial cell.
*May be associated with increased testosterone.
 
===Gross===
*Solid, lobulated.
*Red/tan.
 
Image:
*[http://www.flickr.com/photos/35441329@N05/5056465301/sizes/m/in/photostream/ Leydig cell tumour (flickr.com)].
 
===Microscopic===
Features:<ref name=Ref_GUP581>{{Ref GUP|581}}</ref>
*Vacuolization (cytoplasm) - '''key feature'''.
*Cytoplasm - clear to eosinophilic - '''important'''.
*''Reinke crystals'' - classic finding, usually not present.
**Cylindrical crystalloid eosinophilic cytoplasmic bodies.
*Nucleoli common.
*Round nuclei.
 
DDx:
*[[Spermatocytic seminoma]] - may have eosinophilic cytoplasm.
*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies.
 
====Images====
<gallery>
Image:Leydig_cell_tumour1.jpg |Leydig cell tumour - low mag. (WC)
Image:Leydig_cell_tumour2.jpg |Leydig cell tumour - intermed. mag. (WC)
Image:Leydig_cell_tumour3.jpg |Leydig cell tumour - high mag. (WC)
</gallery>
www:
*[http://path.upmc.edu/cases/case404.html Leydig cell tumour - several images (upmc.edu)].
 
===IHC===
*Inhibin-alpha.
*Calretinin.<ref>URL: [http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm]. Accessed on: 18 May 2010.</ref><ref name=pmid15950053>{{cite journal |author=Bar-Shira Maymon B, Yavetz H, Yogev L, ''et al.'' |title=Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia |journal=Acta Histochem. |volume=107 |issue=2 |pages=105–12 |year=2005 |pmid=15950053 |doi=10.1016/j.acthis.2005.02.002 |url=}}</ref>
*Melan A.<ref name=pmid12966351>{{cite journal |author=Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN |title=Melan-A (A103) and inhibin expression in ovarian neoplasms |journal=Appl. Immunohistochem. Mol. Morphol. |volume=11 |issue=3 |pages=244–9 |year=2003 |month=September |pmid=12966351 |doi= |url=}}</ref>
**AKA ''MART-1''.
**Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours.


==Sertoli cell nodule==
==Sertoli cell nodule==
Michael
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