Difference between revisions of "Uterine tumours"

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Uterine tumours (view source)

Revision as of 03:23, 17 November 2013

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→‎Endometrial stromal sarcoma: split-out
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*Abbreviated ESS.
*Abbreviated ESS.
*[[AKA]] ''low-grade endometrial stromal sarcoma''.
*[[AKA]] ''low-grade endometrial stromal sarcoma''.
===General===
{{Main|Endometrial stromal sarcoma}}
*Rare.<ref name=pmid20179433> {{Cite journal  | last1 = Chew | first1 = I. | last2 = Oliva | first2 = E. | title = Endometrial stromal sarcomas: a review of potential prognostic factors. | journal = Adv Anat Pathol | volume = 17 | issue = 2 | pages = 113-21 | month = Mar | year = 2010 | doi = 10.1097/PAP.0b013e3181cfb7c2 | PMID = 20179433 }}</ref>
 
===Microscopic===
Features:
*Highly cellular Islands with a wavy irregular border.
**Border has finger-like projections/[[tongue]]-like projections.
**Benign uterine smooth muscle between islands of tumour cells.
*Epithelioid cells.
*High [[NC ratio]].
*Thin blood vessels within islands of cells.
**Tumour cells pallisade around the vessels.
 
Notes:
*Vaguely resembles the stroma of proliferative endometrium.
 
DDx:
*[[Leiomyoma]].
*[[Endometrial stromal nodule]].
*[[Uterine leiomyosarcoma]].
 
Images:
*[http://commons.wikimedia.org/wiki/File:EndometrialStromalSarcoma.JPG ESS (WC)].
*[http://commons.wikimedia.org/wiki/File:EndometrialStromalSarcomaLowGrade.JPG Endometrial stromal sarcoma - low grade (WC)].
*[http://jcp.bmj.com/content/60/3/235/F5.large.jpg ESS in an article with many crappy images].<ref name=pmid17347285>{{Cite journal  | last1 = Baker | first1 = P. | last2 = Oliva | first2 = E. | title = Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. | journal = J Clin Pathol | volume = 60 | issue = 3 | pages = 235-43 | month = Mar | year = 2007 | doi = 10.1136/jcp.2005.031203 | PMID = 17347285 | url = http://jcp.bmj.com/content/60/3/235.full }}</ref>
*[http://radiographics.rsna.org/content/25/1/21/F42.expansion.html ESS (rsna.org)].
 
===IHC===
Features:<ref name=pmid14751141>{{Cite journal  | last1 = Zhu | first1 = XQ. | last2 = Shi | first2 = YF. | last3 = Cheng | first3 = XD. | last4 = Zhao | first4 = CL. | last5 = Wu | first5 = YZ. | title = Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. | journal = Gynecol Oncol | volume = 92 | issue = 1 | pages = 71-9 | month = Jan | year = 2004 | doi =  | PMID = 14751141 }}</ref>
*CD10 +ve.
*h-caldesmin -ve.
**[[Leiomyoma]]s +ve.
*PR +/-ve.
*ER +/-ve.
 
===Molecular===
May be associated a recurrent [[translocation]]:<ref name=pmid12648605>{{Cite journal  | last1 = Amant | first1 = F. | last2 = Moerman | first2 = P. | last3 = Cadron | first3 = I. | last4 = Hagemeijer | first4 = A. | last5 = Vergote | first5 = I. | last6 = Debiec-Rychter | first6 = M. | title = Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature. | journal = Gynecol Oncol | volume = 88 | issue = 3 | pages = 459-62 | month = Mar | year = 2003 | doi =  | PMID = 12648605 | URL =  http://www.sciencedirect.com/science/article/pii/S0090825802000963 }}</ref>
*t(7;17)(p15;q21).
**JAZF1 - chromosome 7.<ref name=omim606246>{{OMIM|606246}}</ref>
**SUZ12 - chromosome 17.<ref name=omim606245>{{OMIM|606245}}</ref>


==Undifferentiated endometrial sarcoma==
==Undifferentiated endometrial sarcoma==
Michael
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