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Difference between revisions of "Dysplastic nevus"
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**Joining of three or more adjacent rete ridges = suspicious for melanoma.<ref name=pmid15509670/> | **Joining of three or more adjacent rete ridges = suspicious for melanoma.<ref name=pmid15509670/> | ||
*Draping fibrous tissue - "lamellar fibrosis" - collagen deep to epidermis. | *Draping fibrous tissue - "lamellar fibrosis" - collagen deep to epidermis. | ||
* | *Nuclear atypia - often moderate (small nucleoli visible with 20x objective) - see ''grading'' section. | ||
*+/-Junctional component (cells in the epidermis at the DE junction) larger than the intradermal component - ''shoulder phenomenon''. | *+/-Junctional component (cells in the epidermis at the DE junction) larger than the intradermal component - ''shoulder phenomenon''. | ||
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**A two-tier grading system also exists (''low-grade'' (leave it alone) / ''high-grade'' (cut it out)). | **A two-tier grading system also exists (''low-grade'' (leave it alone) / ''high-grade'' (cut it out)). | ||
**Some pathologists do not grade dysplastic nevi. | **Some pathologists do not grade dysplastic nevi. | ||
*Normal melanocytes have a nucleus that is ~70% the size of a resting basal keratocyte nucleus. | |||
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