Difference between revisions of "Kidney tumours"

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Kidney tumours (view source)

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==Collecting duct carcinoma==
==Collecting duct carcinoma==
*[[AKA]] ''Bellini duct carcinoma'',<ref name=pmid21393935>{{Cite journal  | last1 = Stamatiou | first1 = K. | last2 = Zizi-Sermpetzoglou | first2 = A. | title = Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 229-30 | month =  | year =  | doi = 10.4103/0377-4929.77425 | PMID = 21393935 }}</ref> [[AKA]] ''carcinoma of the collecting ducts of Bellini''.
{{Main|Collecting duct carcinoma}}
 
===General===
*Rare.
*Poor prognosis.
*Usu. central location.
*Typically young adults.
 
===Microscopic===
Features:<ref name=Ref_GUP295>{{Ref GUP|295}}</ref>
*Tubular structures with tapered ends.
**May be described as ''tubulopapillary''.
*[[Hobnail pattern]] - cell width smaller at basement membrane than free surface.<ref name=Ref_PBoD1018>{{Ref PBoD|1018}}</ref>
*High grade nuclear features (nuclear pleomorphism).
*High mitotic rate.
 
Notes:
*Benign urothelium must present to excluded urothelial carcinoma.
*Desmoplastic stroma may be prominent.
 
DDx:
*[[Papillary renal cell carcinoma]] - type 2.
*[[Urothelial carcinoma]] with glandular differentiation.
*Metastatic [[adenocarcinoma]].
*[[Renal medullary carcinoma]] - typically younger, sickle cell trait.
 
====Images====
www:
*[http://webpathology.com/image.asp?case=69&n=1 CDC (webpathology.com)].
*[http://webpathology.com/image.asp?n=2&Case=69 CDC - showing hobnail pattern (webpathology.com)].
*[http://radiographics.rsna.org/content/26/6/1795/F17.expansion.html CDC (rsna.org)].<ref name=pmid17102051>{{Cite journal  | last1 = Prasad | first1 = SR. | last2 = Humphrey | first2 = PA. | last3 = Catena | first3 = JR. | last4 = Narra | first4 = VR. | last5 = Srigley | first5 = JR. | last6 = Cortez | first6 = AD. | last7 = Dalrymple | first7 = NC. | last8 = Chintapalli | first8 = KN. | title = Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation. | journal = Radiographics | volume = 26 | issue = 6 | pages = 1795-806; discussion 1806-10 | month =  | year =  | doi = 10.1148/rg.266065010 | PMID = 17102051 }}</ref>
 
===IHC===
Features:<ref name=pmid19494850>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 | URL = http://www.nature.com/modpathol/journal/v22/n2s/full/modpathol200970a.html }}</ref>
*HMWCK +ve.
*LMWCK +ve.
*CD117 +ve.
*E-cadherin +ve.
*CD10 -ve.
*AMACR -ve.
 
UCC:
*CK20 +ve.<ref name=pmid19494850/>
*p63 +ve.
*CK5/6 +ve.
 
Others:
*CK7 +ve.<ref name=pmid12613443>{{Cite journal  | last1 = Kim | first1 = MK. | last2 = Kim | first2 = S. | title = Immunohistochemical profile of common epithelial neoplasms arising in the kidney. | journal = Appl Immunohistochem Mol Morphol | volume = 10 | issue = 4 | pages = 332-8 | month = Dec | year = 2002 | doi =  | PMID = 12613443 }}</ref>


==Renal medullary carcinoma==
==Renal medullary carcinoma==
Michael
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