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Difference between revisions of "Collecting duct carcinoma"
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Collecting duct carcinoma (view source)
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'''Collecting duct carcinoma''', also known as '''Bellini duct carcinoma'''<ref name=pmid21393935>{{Cite journal | last1 = Stamatiou | first1 = K. | last2 = Zizi-Sermpetzoglou | first2 = A. | title = Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 229-30 | month = | year = | doi = 10.4103/0377-4929.77425 | PMID = 21393935 }}</ref> and '''carcinoma of the collecting ducts of Bellini''', is a rare aggressive [[kidney tumour]]. | |||
==General== | |||
*Rare. | |||
*Poor prognosis. | |||
*Usu. central location. | |||
*Typically young adults. | |||
==Microscopic== | |||
Features:<ref name=Ref_GUP295>{{Ref GUP|295}}</ref> | |||
*Tubular structures with tapered ends. | |||
**May be described as ''tubulopapillary''. | |||
*[[Hobnail pattern]] - cell width smaller at basement membrane than free surface.<ref name=Ref_PBoD1018>{{Ref PBoD|1018}}</ref> | |||
*High grade nuclear features (nuclear pleomorphism). | |||
*High mitotic rate. | |||
Notes: | |||
*Benign urothelium must present to excluded urothelial carcinoma. | |||
*Desmoplastic stroma may be prominent. | |||
DDx: | |||
*[[Papillary renal cell carcinoma]] - type 2. | |||
*[[Urothelial carcinoma]] with glandular differentiation. | |||
*Metastatic [[adenocarcinoma]]. | |||
*[[Renal medullary carcinoma]] - typically younger, sickle cell trait. | |||
===Images=== | |||
www: | |||
*[http://webpathology.com/image.asp?case=69&n=1 CDC (webpathology.com)]. | |||
*[http://webpathology.com/image.asp?n=2&Case=69 CDC - showing hobnail pattern (webpathology.com)]. | |||
*[http://radiographics.rsna.org/content/26/6/1795/F17.expansion.html CDC (rsna.org)].<ref name=pmid17102051>{{Cite journal | last1 = Prasad | first1 = SR. | last2 = Humphrey | first2 = PA. | last3 = Catena | first3 = JR. | last4 = Narra | first4 = VR. | last5 = Srigley | first5 = JR. | last6 = Cortez | first6 = AD. | last7 = Dalrymple | first7 = NC. | last8 = Chintapalli | first8 = KN. | title = Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation. | journal = Radiographics | volume = 26 | issue = 6 | pages = 1795-806; discussion 1806-10 | month = | year = | doi = 10.1148/rg.266065010 | PMID = 17102051 }}</ref> | |||
==IHC== | |||
Features:<ref name=pmid19494850>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 | URL = http://www.nature.com/modpathol/journal/v22/n2s/full/modpathol200970a.html }}</ref> | |||
*HMWCK +ve. | |||
*LMWCK +ve. | |||
*CD117 +ve. | |||
*E-cadherin +ve. | |||
*CD10 -ve. | |||
*AMACR -ve. | |||
UCC: | |||
*CK20 +ve.<ref name=pmid19494850/> | |||
*p63 +ve. | |||
*CK5/6 +ve. | |||
Others: | |||
*CK7 +ve.<ref name=pmid12613443>{{Cite journal | last1 = Kim | first1 = MK. | last2 = Kim | first2 = S. | title = Immunohistochemical profile of common epithelial neoplasms arising in the kidney. | journal = Appl Immunohistochem Mol Morphol | volume = 10 | issue = 4 | pages = 332-8 | month = Dec | year = 2002 | doi = | PMID = 12613443 }}</ref> | |||
==See also== | |||
*[[Kidney tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Kidney tumours]] | |||