Difference between revisions of "Kidney tumours"

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→‎Clear cell papillary renal cell carcinoma: split-out
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==Clear cell papillary renal cell carcinoma==
==Clear cell papillary renal cell carcinoma==
*[[AKA]] ''clear cell tubulopapillary renal cell carcinoma''.<ref name=pmid21602815>{{Cite journal  | last1 = Rohan | first1 = SM. | last2 = Xiao | first2 = Y. | last3 = Liang | first3 = Y. | last4 = Dudas | first4 = ME. | last5 = Al-Ahmadie | first5 = HA. | last6 = Fine | first6 = SW. | last7 = Gopalan | first7 = A. | last8 = Reuter | first8 = VE. | last9 = Rosenblum | first9 = MK. | title = Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1207-20 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.80 | PMID = 21602815 }}</ref>
{{Clear cell papillary renal cell carcinoma}}
*Abbreviation ''CCPRCC''.
 
===General===
*New entity not in the WHO classification.
 
===Microscopic===
Features:<ref name=pmid21602815/>
*Features of both:
*#Clear cell RCC.
*#Papillary RCC.
*#*Often do not have true papillae.
*Apical nuclei - '''key feature'''.<ref>{{Cite journal  | last1 = Bing | first1 = Z. | last2 = Tomaszewski | first2 = JE. | title = Case Report: Clear Cell Papillary Renal Cell Carcinoma in the  Bilateral Native Kidneys after 2 Years of Renal Transplantation:  Report of a Case and Review of  the Literature. | journal = Case Reports in Transplantation | volume = 2011 | issue = | pages =  | month =  | year = 2011 | doi = 10.1155/2011/387645 | PMID =  | url = http://www.hindawi.com/crim/transplantation/2011/387645/cta/ }}</ref>
**In most glandular structures the nuclei are usu. basally located, i.e. in the cytoplasm adjacent to the basement membrane.
 
DDx:
*[[Papillary renal cell carcinoma]].
*[[Clear cell renal cell carcinoma]]
*[[Xp11.2 translocation carcinoma]].
 
====Images====
<gallery>
Image:Clear_cell_papillary_renal_cell_carcinoma_-_high_mag.jpg | CCPRCC - high mag. (WC/Nephron)
Image:Clear_cell_papillary_renal_cell_carcinoma_-_very_high_mag.jpg | CCPRCC - very high mag. (WC/Nephron)
</gallery>
www:
*[http://path.upmc.edu/cases/case682.html Clear cell papillary RCC - several images (upmc.edu)].
*[http://www.flickr.com/photos/40764007@N08/7177459461/ CCPRCC (flickr.com)].
===IHC===
Features:<ref name=pmid21602815/>
*CK7 +ve.
**Usually -ve in clear cell RCC.
*CD10 -ve.
**Usually +ve in clear cell RCC.
**Positive in Xp11.2 translocation carcinoma.<ref name=pmid21804394>{{Cite journal  | last1 = He | first1 = H. | last2 = Zhou | first2 = GX. | last3 = Zhou | first3 = M. | last4 = Chen | first4 = L. | title = The distinction of clear cell carcinoma of the female genital tract, clear cell renal cell carcinoma, and translocation-associated renal cell carcinoma: an immunohistochemical study using tissue microarray. | journal = Int J Gynecol Pathol | volume = 30 | issue = 5 | pages = 425-30 | month = Sep | year = 2011 | doi = 10.1097/PGP.0b013e318214dd4f | PMID = 21804394 }}</ref>
*TFE3 -ve.
**By definition +ve in [[Xp11.2 translocation carcinoma]].
*AMACR -ve.
**Usu. +ve in [[Papillary RCC]].
*Smooth muscle actin +ve (focal).<ref name=pmid23238627>{{Cite journal  | last1 = Williamson | first1 = SR. | last2 = Eble | first2 = JN. | last3 = Cheng | first3 = L. | last4 = Grignon | first4 = DJ. | title = Clear cell papillary renal cell carcinoma: differential diagnosis and extended immunohistochemical profile. | journal = Mod Pathol | volume = 26 | issue = 5 | pages = 697-708 | month = May | year = 2013 | doi = 10.1038/modpathol.2012.204 | PMID = 23238627 }}</ref>
 
Others:<ref name=pmid21602815/>
*HIF-1alpha +ve.
*GLUT-1 +ve.
 
How to remember: ''The two key stains are opposite of what the name implies''.
*''Clear cell'' RCC: CK7 negative.  In this tumour it is the opposite - CK7 is positive.
*''Papillary'' RCC: AMACR positive.  In this tumour it is the opposite - AMACR is negative.


==Unclassified renal cell carcinoma==
==Unclassified renal cell carcinoma==
Michael
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