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Difference between revisions of "Chromophobe renal cell carcinoma"
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Chromophobe renal cell carcinoma (view source)
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Oncocytic_chromophobe_rcc_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Oncocytic variant of chromophobe renal cell carcinoma. [[H&E stain]]. | ||
| Micro = pale cytoplasm, with wisps of eosinophilic material, perinuclear clearing (a pale halo surrounds the nucleus), periphery of cell distinct (cell membrane is easy to discern -- plant cell-like) | | Micro = pale cytoplasm, with wisps of eosinophilic material, perinuclear clearing (a pale halo surrounds the nucleus), periphery of cell distinct (cell membrane is easy to discern -- plant cell-like) | ||
| Subtypes = eosinophilic variant | | Subtypes = eosinophilic variant | ||
| Line 16: | Line 16: | ||
| Site = [[kidney]] - see [[renal tumours]] | | Site = [[kidney]] - see [[renal tumours]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = [[Birt–Hogg–Dubé syndrome]] | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
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*Least common of the common types of RCC ([[clear cell RCC]], [[papillary RCC]], [[chromophobe RCC]]). | *Least common of the common types of RCC ([[clear cell RCC]], [[papillary RCC]], [[chromophobe RCC]]). | ||
*''Fuhrman grading'' for this entity is controversial, as it does not appear to have any predictive value.<ref name=pmid17527087>{{Cite journal | last1 = Delahunt | first1 = B. | last2 = Sika-Paotonu | first2 = D. | last3 = Bethwaite | first3 = PB. | last4 = McCredie | first4 = MR. | last5 = Martignoni | first5 = G. | last6 = Eble | first6 = JN. | last7 = Jordan | first7 = TW. | title = Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. | journal = Am J Surg Pathol | volume = 31 | issue = 6 | pages = 957-60 | month = Jun | year = 2007 | doi = 10.1097/01.pas.0000249446.28713.53 | PMID = 17527087 }}</ref> | *''Fuhrman grading'' for this entity is controversial, as it does not appear to have any predictive value.<ref name=pmid17527087>{{Cite journal | last1 = Delahunt | first1 = B. | last2 = Sika-Paotonu | first2 = D. | last3 = Bethwaite | first3 = PB. | last4 = McCredie | first4 = MR. | last5 = Martignoni | first5 = G. | last6 = Eble | first6 = JN. | last7 = Jordan | first7 = TW. | title = Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. | journal = Am J Surg Pathol | volume = 31 | issue = 6 | pages = 957-60 | month = Jun | year = 2007 | doi = 10.1097/01.pas.0000249446.28713.53 | PMID = 17527087 }}</ref> | ||
*May be associated with [[Birt–Hogg–Dubé syndrome]].<ref name=Ref_WMSP290>{{Ref WMSP|290}}</ref> | |||
There are two subtypes:<ref name=Ref_GUP293>{{Ref GUP|293}}</ref> | There are two subtypes:<ref name=Ref_GUP293>{{Ref GUP|293}}</ref> | ||