Difference between revisions of "Non-malignant skin disease"

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Non-malignant skin disease (view source)

Revision as of 01:48, 31 October 2013

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→‎Necrobiosis lipoidica: split-out
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==Necrobiosis lipoidica==
==Necrobiosis lipoidica==
===General===
{{Main|Necrobiosis lipoidica}}
Associated with:
*[[Diabetes mellitus]] - known as ''necrobiosis lipoidica diabeticorum''.
*[[Rheumatoid arthritis]].
 
===Gross===
 
Image:
<gallery>
Image:Necrobiosislipoidica.jpg | Necrobiosis lipoidica. (WC)
</gallery>
 
===Microscopic===
Features:<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
*Dermal palisading [[granuloma]] around:
**Necrotic collagen - '''key feature'''.
***Nuclei "missing" - have undergone karyolysis.
*Little mucin, no normal dermis between foci.
*Plasma cells - common.<ref name=dermnetnz_nl>URL: [http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html]. Accessed on: 24 January 2012.</ref>
*May involve adipose tissue.
 
DDx:
*[[Granuloma annulare|Granuloma a'''nn'''ulare]] - '''m'''ore '''m'''ucin, normal dermis between foci,<ref name=Ref_Derm51>{{Ref Derm|51}}</ref> plasma cells uncommon,<ref name=dermnetnz_nl/> no fat involvement - usu. more superficial.
*[[Rheumatoid nodule]].
 
====Images====
<gallery>
Image:Necrobiosis_lipoidica_-_low_mag.jpg | Necrobiosis lipoidica - low mag. (WC)
</gallery>
www:
*[http://dermatology.cdlib.org/103/NYU/case_presentations/042004n10.html Necrobiosis lipoidica (dermatology.cdlib.org)].
*[http://www.drmihm.com/cases/case.cfm?CaseID=53 Necrobiosis lipoidica (drmihm.com)].
*[http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html Necrobiosis lipoidica (dermnetnz.org)].


==Keloid==
==Keloid==
Michael
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