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Difference between revisions of "Neuromuscular pathology"
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Neuromuscular pathology (view source)
Revision as of 03:33, 2 November 2010
, 03:33, 2 November 2010→Dermatomyositis: more, refs
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==Dermatomyositis== | ==Dermatomyositis== | ||
===General=== | ===General=== | ||
*Complement mediated disease | *Complement mediated disease - membrane attack complex. | ||
*Usually middle age. | *Usually middle age. | ||
*Associated skin rash is common. | *Associated skin rash is common. | ||
====Clinical==== | |||
*If the characteristic skin lesions are absent... it is likely ''idiopathic inflammatory myositis'' and related to ''[[diabetes mellitus]]''.<ref name=pmid20536597>{{cite journal |author=Limaye VS, Lester S, Blumbergs P, Roberts-Thomson PJ |title=Idiopathic inflammatory myositis is associated with a high incidence of hypertension and diabetes mellitus |journal=Int J Rheum Dis |volume=13 |issue=2 |pages=132–7 |year=2010 |month=May |pmid=20536597 |doi=10.1111/j.1756-185X.2010.01470.x |url=}}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Perifascicular inflammation with perifascicular atrophy - '''key feature'''. | *Perifascicular inflammation with perifascicular atrophy - '''key feature'''. | ||
*Loss of vessels around muscle fibres. | |||
**Vessels should be where more than 3 or more fibres are opposed to one another. | |||
===EM=== | |||
*Tubuloreticular inclusions;<ref name=pmid19330338>{{cite journal |author=Stoltenburg-Didinger G, Genth E |title=[Dermatomyositis] |language=German |journal=Z Rheumatol |volume=68 |issue=4 |pages=287–94 |year=2009 |month=June |pmid=19330338 |doi=10.1007/s00393-008-0398-y |url=}}</ref> not pathognomonic - may be seen in inclusion body myositis.<ref name=pmid20569678>{{cite journal |author=Katzberg HD, Munoz DG |title=Tubuloreticular inclusions in inclusion body myositis |journal=Clin. Neuropathol. |volume=29 |issue=4 |pages=262–6 |year=2010 |pmid=20569678 |doi= |url=}}</ref> | |||
==Inclusion body myositis== | ==Inclusion body myositis== | ||