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'''Trichoblastoma''', also known as '''trichoepithelioma''', is an uncommon [[dermatologic neoplasms|skin tumour]]. | |||
''Trichoepithelioma'' is considered a superficial version of trichoblastoma; the World Health Organization lumps the two entities together.<ref name=Ref_Derm383>{{Ref Derm|383}}</ref> | |||
==General== | |||
*Benign. | |||
**Maligant counterpart of trichoepithelioma: [[trichilemmal carcinoma]]. | |||
*May be familial: | |||
**Multiple familial trichoepithelioma.<ref name=pmid15289313>{{Cite journal | last1 = Salhi | first1 = A. | last2 = Bornholdt | first2 = D. | last3 = Oeffner | first3 = F. | last4 = Malik | first4 = S. | last5 = Heid | first5 = E. | last6 = Happle | first6 = R. | last7 = Grzeschik | first7 = KH. | title = Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene. | journal = Cancer Res | volume = 64 | issue = 15 | pages = 5113-7 | month = Aug | year = 2004 | doi = 10.1158/0008-5472.CAN-04-0307 | PMID = 15289313 }}</ref> | |||
**Brooke-Spiegler syndrome. | |||
==Microscopic== | |||
Features:<ref>URL: [http://emedicine.medscape.com/article/1060049-workup#a0723 http://emedicine.medscape.com/article/1060049-workup#a0723]. Accessed on: 31 August 2011.</ref> | |||
*Well-circumscribed cell nest in the superficial dermis. | |||
*Surrounding by a fibrous stroma. | |||
*Basaloid cells with [[peripheral palisading]]. | |||
*+/-Surround keratin-filled cysts. | |||
*Fibroblasts-like cell aggregate, similar to a follicular papillae (papillary-mesenchymal body). | |||
Notes: | |||
*Very rarely an artefactual cleft - as in [[basal cell carcinoma]]. | |||
Variants: | |||
*Desmoplastic trichoblastoma. | |||
DDx: | |||
*[[Basal cell carcinoma]] - usu. mitoses, [[myxoid stroma]] and '''no''' papillary-mesenchymal bodies. | |||
*[[Dermal cylindroma]] - has hyaline stroma. | |||
*[[Trichofolliculoma]]. | |||
*[[Sebaceous carcinoma]], well-differentiated - has some cells with clear vacuolated cytoplasm. | |||
===Images=== | |||
<gallery> | |||
Image:Trichoepithelioma_-_low_mag.jpg | Trichoepithelioma - low mag. (WC/Nephron) | |||
Image:Trichoepithelioma_-_high_mag.jpg | Trichoepithelioma - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://img.medscape.com/pi/emed/ckb/dermatology/1048885-1055824-1060049-1348744.jpg Papillary-mesenchymal body (medscape.com)].<ref>URL: [http://emedicine.medscape.com/article/1060049-workup#a0723 http://emedicine.medscape.com/article/1060049-workup#a0723 Papillary-mesenchymal body (emedicine.medscape.com)]. Accessed on: 22 August 2012.</ref> | |||
*[http://skinpathologyatlas.com/tumors/hair/images/trichofollic-20x-pal.jpg Papillary-mesenchymal body (skinpathologyatlas.com)].<ref>URL: [http://skinpathologyatlas.com/tumors/hair/trichofollic.htm http://skinpathologyatlas.com/tumors/hair/trichofollic.htm]. Accessed on: 22 August 2012.</ref> | |||
*[http://www.dermnetnz.org/common/image.php?path=/pathology/img/t/trichoepitheliomafigure3.jpg Trichoepithelioma (dermnetnz.org)]. | |||
==Sign out== | |||
<pre> | |||
SKIN LESION, NOSE, BIOPSY: | |||
- TRICHOBLASTOMA, COMPLETELY EXCISED. | |||
</pre> | |||
===Micro=== | |||
The sections show well-circumscribed dermal nests of basaloid cells with peripheral palisading surrounded by a dense fibrous stroma. There is no artefactual clefting between the stroma and basaloid cell nests. Mitotic activity is minimal. Smaller hyperchromatic spindled-to-epithelioid cells in clusters (papillary-mesenchymal bodies) are found within the basaloid cells nests. | |||
The epidermis show maturation to the surface and does not have basal atypia. | |||
The lesion is completely excised in the plane of section. | |||
==See also== | |||
*[[Dermatologic neoplasms]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Dermatologic neoplasms]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||