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Difference between revisions of "Nucleus-to-cytoplasm ratio"
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Nucleus-to-cytoplasm ratio (view source)
Revision as of 12:29, 8 October 2013
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'''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated '''NC ratio'''. | '''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated '''NC ratio'''. | ||
High NC ratio is strong predictor of malignancy.<ref name=pmid16556320>{{Cite journal | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue = | pages = 11 | month = | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }} | High NC ratio is strong predictor of [[malignancy]].<ref name=pmid16556320>{{Cite journal | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue = | pages = 11 | month = | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }} | ||
</ref> Like very rule, there are exceptions. | </ref> Like very rule, there are exceptions. | ||
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===High NC ratio in cancer=== | ===High NC ratio in cancer=== | ||
The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the ''[[small round cell tumour]]'' group. | The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the large ''[[small round cell tumour]]'' group. | ||
*Many other tumours. | *Many other tumours - see ''[[A long differential diagnosis of small blue cell tumours]]''. | ||
===Atypical cells with a normal NC ratio=== | ===Atypical cells with a normal NC ratio=== | ||
*[[Radiation changes]]. | *[[Radiation changes]] - [[clinical history]] is important! | ||
*Many tumours. | |||
==See also== | ==See also== | ||