Difference between revisions of "Spindle cell lesions"

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Spindle cell lesions (view source)

Revision as of 22:51, 6 October 2013

9,596 bytes added ,  22:51, 6 October 2013
→‎General DDx
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*Other.
*Other.
**Carcinoma, e.g. metaplastic carcinoma.
**Carcinoma, e.g. metaplastic carcinoma.
===Long DDx===
{| class="wikitable sortable"
| [[Malignant melanoma]]
| melanoma
| 
|-
| [[PEComa]]
| mesenchymal lesion
|[[angiomyolipoma]], [[lymphangioleiomyomatosis]], other PEComas
|-
| [[Sarcomatoid carcinoma]]
| carcinoma
| 
|-
| [[Desmoplastic-spindle cell mesothelioma]]
| carcinoma
| 
|-
| [[Thymoma]]
| epithelial lesion
| 
|-
| [[Spindle epithelial tumor with thymus-like differentiation]]
| epithelial lesion
| 
|-
| [[Malignant phylloides tumour]]
| sarcoma
| 
|-
| [[Chondroid syringoma]]
| epithelial lesion
| 
|-
| [[Mixed Muellerian Tumour]]
| carcinoma
| 
|-
| [[Syphilis]]
| infection
| 
|-
| [[Bacillary angiomatosis]]
| infection
| 
|-
| [[Myocbacterial spindle cell pseudotumour]]
| infection
| 
|-
| [[Cryotococcal pseudotumour]]
| infection
| 
|-
| [[Anaplastic large cell lymphoma]]
| lymphoid
| 
|-
| [[Lymphocyte-depleted Hodgkin lymphoma]]
| lymphoid
| 
|-
| [[Follicular dendritic cell sarcoma]]
| sarcoma
| 
|-
| [[Interdigitating reticulum cell sarcoma]]
| sarcoma
| 
|-
| [[Sclerosing extramedullary hematopoetic tumours]]
| other
|seen in chronic [[myeloproliferative disorders]]<ref name=pmid10632487>{{Cite journal| last1 = Remstein| first1 = ED.| last2 = Kurtin| first2 = PJ.| last3 = Nascimento| first3 = AG.| title = Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative disorders.| journal = Am J Surg Pathol| volume = 24| issue = 1| pages = 51-5| month = Jan| year = 2000| doi =| PMID = 10632487 }}</ref>
|-
| [[Juvenile xanthogranuloma]]
| histiocytic lesion
| 
|-
| [[Granuloma annulare]]
| histiocytic lesion
| 
|-
| [[Crystal-storing histiocytosis]]
| histiocytic lesion
| 
|-
| [[Schwannoma]]
| neural tumours
| 
|-
| [[Neurofibroma]]
| neural tumours
| 
|-
| [[Malignant peripheral nerve sheath tumour]]
| neural tumours
| 
|-
| [[Perineurioma]]
| neural tumours
| 
|-
| [[Sustentaculoma of adrenal gland]]
| neural tumours
| 
|-
| [[Mucosal epithelioid nerve sheath tumour]]
| neural tumours
| 
|-
| [[Neurothekeoma]]
| neural tumours
| 
|-
| [[Angiosarcoma]]
| vascular tumours
| 
|-
| [[Kaposi's Sarcoma]]
| vascular tumours
| 
|-
| [[Composite hemangioendothelioma]]
| vascular tumours
| 
|-
| [[Pseudoangiomatous stromal hyperplasia]]
| vascular tumours
| 
|-
| [[Angiolymphoid hyperplasia with eosinophilia]]
| vascular tumours
| 
|-
| [[Kaposiform hemangioendothelioma]]
| vascular tumours
| 
|-
| [[Leiomyosarcoma]]
| muscle tumours
| 
|-
| [[Hyalinizing matrix-rich rhabdomyosarcoma]]
| muscle tumours
|DDx: [[osteosarcoma]], [[chondrosarcoma]]
|-
| [[Spindle cell rhabdomyosarcoma]]
| muscle tumours
| 
|-
| [[Glomangiopericytoma]]
| muscle tumours
| 
|-
| [[Myopericytoma]]
| muscle tumours
| 
|-
| [[Fetal or genital rhabdomyoma]]
| muscle tumours
| 
|-
| [[Spindle cell lipoma]]
| lipomatous tumours
| 
|-
| [[Spindle cell liposarcoma]]
| lipomatous tumours
|<ref name=pmid8067512>{{Cite journal| last1 = Dei Tos| first1 = AP.| last2 = Mentzel| first2 = T.| last3 = Newman| first3 = PL.| last4 = Fletcher| first4 = CD.| title = Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases.| journal = Am J Surg Pathol| volume = 18| issue = 9| pages = 913-21| month = Sep| year = 1994| doi =| PMID = 8067512 }}</ref>
|-
| [[Massive localized lymphedema]]
| lipomatous tumours
|associated with [[obesity]]
|-
| [[Dedifferentiated liposarcoma]]
| lipomatous tumours
| 
|-
| [[Lipoleiomyosarcoma]]
| lipomatous tumours
|<ref name=pmid12023578>{{Cite journal| last1 = Folpe| first1 = AL.| last2 = Weiss| first2 = SW.| title = Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation): a clinicopathologic study of nine cases including one with dedifferentiation.| journal = Am J Surg Pathol| volume = 26| issue = 6| pages = 742-9| month = Jun| year = 2002| doi =| PMID = 12023578 }}</ref>
|-
| [[Spindle cell osteosarcoma]]
| chondro-osseous tumours
| 
|-
| [[Parosteal osteosarcoma]]
| chondro-osseous tumours
| 
|-
| [[Extraskeletal myxoid chondrosarcoma ]]
| chondro-osseous tumours
| 
|-
| [[Fibromatosis]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Desmoid tumour]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Hemorrhagic dermatomyofibroma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Sclerotic "plywood" fibroma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Fibrosarcoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Dermatofibrosarcoma protuberans]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Angiomyofibroblastoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Myofibroblastic sarcoma]], low grade
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Solitary fibrous tumour]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Superficial acral fibromyxoma ]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Diffuse-type tenosynovial giant cell tumour]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Fasciitis-like reactive myofibroblastic proliferation]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Sclerosing epithelioid fibrosarcoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Myxoinflammatory fibroblastic sarcoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Dermatomyofibroma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Myofibrosarcoma]]
| fibroblastic/myofibroblastic tumours
|<ref name=pmid11176071>{{Cite journal| last1 = Montgomery| first1 = E.| last2 = Goldblum| first2 = JR.| last3 = Fisher| first3 = C.| title = Myofibrosarcoma: a clinicopathologic study.| journal = Am J Surg Pathol| volume = 25| issue = 2| pages = 219-28| month = Feb| year = 2001| doi =| PMID = 11176071 }}</ref>
|-
| [[Myofibromatosis-like perivascular myoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Myofibroblastoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[ incl superficial cervicovaginal myofibroblastoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Cellular Angiofibroma]]
| fibroblastic/myofibroblastic tumours
| <ref name=pmid15489646>{{Cite journal  | last1 = Iwasa | first1 = Y. | last2 = Fletcher | first2 = CD. | title = Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases. | journal = Am J Surg Pathol | volume = 28 | issue = 11 | pages = 1426-35 | month = Nov | year = 2004 | doi =  | PMID = 15489646 }}</ref>
|-
| [[Giant cell angiofibroma ]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Myofibroma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Ossifying fibromyxoid tumour of soft parts]]
| fibroblastic/myofibroblastic tumours
| S-100 +ve
|-
| [[Myxofibrosarcoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Pleomorphic undifferentiated sarcoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Atypical fibroxanthoma]]
| fibroblastic/myofibroblastic tumours
| 
|-
| [[Low grade fibromyxoid sarcoma ]]
| fibroblastic/myofibroblastic tumours
| hyalinizing spindle cell tumour with giant rosettes
|-
| [[Inflammatory myofibroblastic tumour]]
| fibroblastic/myofibroblastic tumours
|may be cytokeratin +ve, ALK +ve
|-
| [[Angiomatoid fibrous histiocytoma]]
| fibroblastic/myofibroblastic tumours
| younger individuals
|-
| [[Synovial sarcoma]]
| sarcoma
| 
|-
| [[Gastrointestinal stromal tumour]]
| mesenchymal lesion
| 
|-
| [[Meningioma]]
| other
| fibrous variant
|-
| [[Epithelioid sarcoma]]
| sarcoma
| pseudomyogenic "fibroma-like" variant
|-
| [[Anthracotic & anthracosilicotic spindle cell pseudotumour of mediastinal lymph node]]
| other
| 
|-
| [[Adenosarcoma]]
| sarcoma
| under-sampled glandular component
|-
| [[Mixed Muellerian tumour]]
| sarcoma
| 
|-
| [[Blastemal elements of Wilms' tumour]]
| other
| 
|-
| [[Blastemal elements of pulmonary blastoma]]
| other
| 
|-
| [[Ossifying desmoplastic nested epithelial-stromal tumour of liver]]
| other
| 
|-
| [[Phosphaturic mesenchymal tumour]]
| other
| 
|-
| [[Ectomesenchymoma]]
| other
| skeletal muscle and neural differentiation
|-
| [[Congenital pseudarthosis]] associated with [[neurofibromatosis]]
| other
| 
|-
| [[Endometrial stromal sarcoma]]
| sarcoma
| 
|-
| [[Mixed endometrial stromal and smooth muscle tumour of the uterus]]
| mesenchymal lesion
|<ref name=pmid9706980>{{Cite journal| last1 = Oliva| first1 = E.| last2 = Clement| first2 = PB.| last3 = Young| first3 = RH.| last4 = Scully| first4 = RE.| title = Mixed endometrial stromal and smooth muscle tumors of the uterus: a clinicopathologic study of 15 cases.| journal = Am J Surg Pathol| volume = 22| issue = 8| pages = 997-1005| month = Aug| year = 1998| doi =| PMID = 9706980 }}</ref>
|-
| [[Yolk sac tumour, spindle cell]]
| germ cell tumour
| 
|-
| [[Granulosa cell tumour]]
| sex cord tumour
| 
|-
| [[Thecoma]]
| sex cord tumour
| 
|-
| [[Fibroma]]
| sex cord tumour
| 
|-
| [[Leydig cell tumour, spindle cell]]
| sex cord tumour
|<ref>{{Cite journal| last1 = Ulbright| first1 = TM.| last2 = Srigley| first2 = JR.| last3 = Hatzianastassiou| first3 = DK.| last4 = Young| first4 = RH.| title = Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells.| journal = Am J Surg Pathol| volume = 26| issue = 11| pages = 1424-33| month = Nov| year = 2002| doi =| PMID = 12409718 }}</ref>
|-
| [[Gynandroblastoma]]
| sex cord tumour
|[[Sertoli cell tumour]] & [[granulosa cell tumour]]
|-
|}


==Microscopic==
==Microscopic==
Michael
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