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Difference between revisions of "Chordoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Chordoma_-_high_mag.jpg | |||
| Width = | |||
| Caption = Chordoma. [[HPS stain]]. | |||
| Micro = ''physaliphorous cells'' (also ''bubble cells'') - very large clear bubble with a sharp border, bubble does not compress nucleus; islands of cells surrounded by fibrous tissue; myxoid background | |||
| Subtypes = | |||
| LMDDx = [[chondrosarcoma]], [[myxoid lesions]] | |||
| Stains = | |||
| IHC = S-100 +ve, AE1/AE3 +ve, Brachyury +ve, EMA +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = myxoid | |||
| Grossing = | |||
| Site = sacrum or clivus | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Chordoma''' is an uncommon tumour in [[neuropathology]]. | '''Chordoma''' is an uncommon tumour in [[neuropathology]]. | ||
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DDx: | DDx: | ||
*[[Chondrosarcoma]]. | *[[Chondrosarcoma]]. | ||
*[[Myxoid lesions]]. | |||
===Images=== | ===Images=== | ||
| Line 41: | Line 71: | ||
==IHC== | ==IHC== | ||
Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal | last1 = Coindre | first1 = JM. | last2 = Rivel | first2 = J. | last3 = Trojani | first3 = M. | last4 = De Mascarel | first4 = I. | last5 = De Mascarel | first5 = A. | title = Immunohistological study in chordomas. | journal = J Pathol | volume = 150 | issue = 1 | pages = 61-3 | month = Sep | year = 1986 | doi = 10.1002/path.1711500110 | PMID = 2431128 }}</ref> | Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal | last1 = Coindre | first1 = JM. | last2 = Rivel | first2 = J. | last3 = Trojani | first3 = M. | last4 = De Mascarel | first4 = I. | last5 = De Mascarel | first5 = A. | title = Immunohistological study in chordomas. | journal = J Pathol | volume = 150 | issue = 1 | pages = 61-3 | month = Sep | year = 1986 | doi = 10.1002/path.1711500110 | PMID = 2431128 }}</ref> | ||
* | *S-100 +ve. | ||
*AE1/AE3 +ve. | *AE1/AE3 +ve. | ||
*Brachyury +ve -- '''key stain'''. | *Brachyury +ve -- '''key stain'''. | ||