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Difference between revisions of "Neuropathology tumours"
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m
→Microscopic: +link to image
m (→Chordoma: +loc.) |
m (→Microscopic: +link to image) |
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Features:<ref>DCHH P.184.</ref> | Features:<ref>DCHH P.184.</ref> | ||
*Architecture: islands of cells surrounded by fibrous tissue. | *Architecture: islands of cells surrounded by fibrous tissue. | ||
** | **Also described as "lobulated" architecture; may not be apparent. | ||
*Myxoid background - grey extracellular material. | *Myxoid background - grey extracellular material, variable amount present. | ||
*Mixed cell population: | *Mixed cell population: | ||
*#Abundant eosinophilic cytoplasm | *#Abundant eosinophilic cytoplasm. | ||
*#''Physaliphorous cells'' | *#''Physaliphorous cells'' or ''bubble cells'' - '''key feature'''. | ||
*#*Have a very large clear bubble | *#*Have a very large clear bubble with a sharp border; bubble does not compress nucleus - nucleus may be in bubble. | ||
Image(s): | |||
*[[http://www.surgical-pathology.com/Chordoma4_image.htm Chordoma - crappy quality image (surgical-pathology.com)]. | |||
===IHC=== | |||
Features: | |||
*S100 +ve. | |||
*CK +ve. | |||
*Brachyury +ve. | |||
**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref> | |||
==References== | ==References== | ||