Difference between revisions of "Soft tissue lesions"

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Soft tissue lesions (view source)

Revision as of 03:25, 29 September 2013

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→‎Alveolar soft part sarcoma: split-out
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==Alveolar soft part sarcoma==
==Alveolar soft part sarcoma==
*Abbreviated ''ASPS''.
{{Main|Alveolar soft part sarcoma}}
===General===
*Adolescents/young adults.
*Children -- classically location: base of [[tongue]] and orbit.
*Typical indolent initially - ultimately a poor prognosis.<ref name=pmid17071801>{{Cite journal  | last1 = Folpe | first1 = AL. | last2 = Deyrup | first2 = AT. | title = Alveolar soft-part sarcoma: a review and update. | journal = J Clin Pathol | volume = 59 | issue = 11 | pages = 1127-32 | month = Nov | year = 2006 | doi = 10.1136/jcp.2005.031120 | PMID = 17071801 |PMC = 1860509 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/?tool=pubmed }}</ref>
 
===Microscopic===
Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref>
*Arranged in nest/separated by thin septa; vaguely resembles alveoli (at low power).
*Large cells (~30-50 μm) with abundant eosinophilic cytoplasm.
*An eccentric nucleus.
*+/-Nucleolus.
 
DDx:
*[[Rhabdomyosarcoma]], alveolar - usu. does not have sheets of rhabdoid cells.
 
====Images====
<gallery>
Image:Alveolar_soft_part_sarcoma_-_low_mag.jpg | ASPS - low mag. (WC/Nephron)
Image:Alveolar_soft_part_sarcoma_-_intermed_mag.jpg | ASPS - intermed. mag. (WC/Nephron)
Image:Alveolar_soft_part_sarcoma_-2-_very_high_mag.jpg | ASPS - very high mag. (WC/Nephron)
</gallery>
www:
*[http://www.webpathology.com/image.asp?case=508&n=10 ASPS - PAS (webpathology.com)].
 
===Stains===
*PAS +ve (cytoplasmic) - considered the most useful.<ref name=pmid17516754>{{Cite journal  | last1 = Zarrin-Khameh | first1 = N. | last2 = Kaye | first2 = KS. | title = Alveolar soft part sarcoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 3 | pages = 488-91 | month = Mar | year = 2007 | doi = 10.1043/1543-2165(2007)131[488:ASPS]2.0.CO;2 | PMID = 17516754 }}</ref>
*PASD +ve (cytoplasmic).
 
===IHC===
*TFE3 +ve -- suggestive of characteristic translocation.
 
===Molecular===
*t(X;17)(p11.2;q25).<ref>{{OMIM|606243}}</ref>
 
Note:
*Same translocation may be seen in ''[[renal tumour with Xp11.2 translocation]]''.
 
===EM===
*Distinctive membrane-bound intracytoplasmic crystal lattice with ~5 nm fibres spaced 10 nm apart.<ref name=pmid17071801/>
 
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig8/ Distinctive crystal lattice in ASPS (nlm.nih.gov)].<ref name=pmid17071801/>


==Desmoplastic small round cell tumour==
==Desmoplastic small round cell tumour==
Michael
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