Difference between revisions of "Stomach"

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Stomach (view source)

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→‎Fundic gland polyp: split-out
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==Fundic gland polyp==
==Fundic gland polyp==
*Abbreviated ''FGP''.
{{Main|Fundic gland polyp}}
===General===
*Most common stomach polyp.<ref name=pmid20567540/>
*''Fundic'' location usually.
**May be in the body.<ref name=pmid20567540>{{Cite journal  | last1 = Spiegel | first1 = A. | last2 = Stein | first2 = P. | last3 = Patel | first3 = M. | last4 = Patel | first4 = R. | last5 = Lebovics | first5 = E. | title = A report of gastric fundic gland polyps. | journal = Gastroenterol Hepatol  (N Y) | volume = 6 | issue = 1 | pages = 45-8 | month = Jan | year = 2010 | doi =  | PMID = 20567540 }}</ref>
 
====Clinical significance====
*Weak association with FAP ([[familial adenomatous polyposis]]).<ref name=pmid20567540/><ref name=pmid18322941>{{cite journal |author=Freeman HJ |title=Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis |journal=World J. Gastroenterol. |volume=14 |issue=9 |pages=1318-20 |year=2008 |month=March |pmid=18322941 |doi= |url=http://www.wjgnet.com/1007-9327/14/1318.asp}}</ref>
*Associated with chronic proton pump inhibitors (PPI) use -- approximately 4x risk.<ref>{{cite journal |author=Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH |title=Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy |journal=Aliment. Pharmacol. Ther. |volume=24 |issue=9 |pages=1341-8 |year=2006 |month=November |pmid=17059515 |doi=10.1111/j.1365-2036.2006.03127.x |url=}}</ref>
 
Notes:
*Animal studies suggested PPIs cause [[neuroendocrine tumour]]s -- but this has not been found in humans.<ref>{{cite journal |author=Masaoka T, Suzuki H, Hibi T |title=Gastric epithelial cell modality and proton pump inhibitor |journal=J Clin Biochem Nutr |volume=42 |issue=3 |pages=191-6 |year=2008 |month=May |pmid=18545640 |pmc=2386521 |doi=10.3164/jcbn.2008028 |url=}}</ref>
 
===Microscopic===
Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm]. Accessed on: 19 October 2010.</ref>
*Polypoid shape (may not be appreciated on microscopy).
*Dilated gastric glands.
**Flatted epithelial lining (consisting of normal foveolar epithelium) - '''key feature'''.
 
Notes:
*The presence of dysplastic changes should prompt consideration of ''FAP''.
 
DDx:
*[[Hyperplastic polyp of the stomach]] - has foveolar hyperplasia, gland dilation may be present.
 
Image:
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm Fundic gland polyp (ouhsc.edu)].
 
===Sign out===
<pre>
POLYP, STOMACH, BIOPSY:
- FUNDIC GLAND POLYP.
- NEGATIVE FOR INTESTINAL METAPLASIA.
- NEGATIVE FOR HELICOBACTER-LIKE ORGANISMS.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
</pre>


=Neoplastic=
=Neoplastic=
Michael
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