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Difference between revisions of "Goblet cell adenocarcinoma"
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Goblet cell adenocarcinoma (view source)
Revision as of 14:32, 27 September 2013
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| Subtypes = | | Subtypes = | ||
| LMDDx = [[signet ring cell carcinoma]], [[appendiceal neuroendocrine tumour]] | | LMDDx = [[signet ring cell carcinoma]], [[appendiceal neuroendocrine tumour]] | ||
| Stains = | | Stains = [[alcian blue stain|alcian blue]] +ve, [[PASD stain|PASD]] +ve, [[mucicarmine stain|mucicarmine]] +ve | ||
| IHC = synaptophysin +ve, chromogranin +ve, S-100 +ve, CK20 +ve | | IHC = synaptophysin +ve, chromogranin +ve, S-100 +ve, CK20 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = usu. no mass apparent | ||
| Grossing = | | Grossing = | ||
| Site = [[vermiform appendix]], elsewhere in the GI tract | | Site = [[vermiform appendix]], elsewhere in the GI tract | ||
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| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = moderate | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = [[acute appendicitis]], other appendiceal tumours, other abdominal pathology | ||
}} | }} | ||
'''Crypt cell carcinoma''', also known as '''goblet cell carcinoid'''<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref><ref>{{Cite journal | last1 = Pahlavan | first1 = PS. | last2 = Kanthan | first2 = R. | title = Goblet cell carcinoid of the appendix. | journal = World J Surg Oncol | volume = 3 | issue = | pages = 36 | month = Jun | year = 2005 | doi = 10.1186/1477-7819-3-36 | PMID = 15967038 }}</ref> | '''Crypt cell carcinoma''', also known as '''goblet cell carcinoid'''<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref><ref>{{Cite journal | last1 = Pahlavan | first1 = PS. | last2 = Kanthan | first2 = R. | title = Goblet cell carcinoid of the appendix. | journal = World J Surg Oncol | volume = 3 | issue = | pages = 36 | month = Jun | year = 2005 | doi = 10.1186/1477-7819-3-36 | PMID = 15967038 }}</ref> | ||
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*Rare appendiceal tumour that typically has an aggressive course vis-a-vis other appendiceal carcinoids.<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref> | *Rare appendiceal tumour that typically has an aggressive course vis-a-vis other appendiceal carcinoids.<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref> | ||
*Mixed (biphasic) tumour with endocrine and exocrine features. | *Mixed (biphasic) tumour with endocrine and exocrine features. | ||
*Usually presents as [[acute appendicitis]].<ref name=pmid15967038/> | |||
**Less common presentations: appendiceal mass, pain. | |||
*Five year survival in one series: 60-85%.<ref name=pmid15967038/> | |||
==Gross== | |||
*Typically no mass is apparent at gross.<ref name=pmid15967038/> | |||
==Microscopic== | ==Microscopic== | ||
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==Stains== | ==Stains== | ||
*Mucin stains +ve: | *Mucin stains +ve: | ||
**Mucicarmine, perodic acid-Schiff diastase (PAS-D), | **Mucicarmine, perodic acid-Schiff diastase (PAS-D), alcian blue. | ||
==IHC== | |||
*Classic neuroendocrine markers: | *Classic neuroendocrine markers: | ||
**Synaptophysin +ve. | **Synaptophysin +ve. | ||