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Difference between revisions of "Basics"
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→Dyscohesive versus cohesive
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#Nucleoli - number (absent, present, multiple). | #Nucleoli - number (absent, present, multiple). | ||
#*Large [[nucleoli]] (nucleoli seen with the 10x objective) pretty much exclude neuroendocrine. | #*Large [[nucleoli]] (nucleoli seen with the 10x objective) pretty much exclude neuroendocrine. | ||
======Types of cells====== | |||
{| class="wikitable sortable" | |||
! Type | |||
! Morphology | |||
! Significance | |||
|- | |||
| [[Spindle cell]] | |||
| tapered at both ends<ref>URL: [http://www.medterms.com/script/main/art.asp?articlekey=25657 http://www.medterms.com/script/main/art.asp?articlekey=25657]. Accessed on: 18 January 2010.</ref> | |||
| suggestive of sarcoma - compatible with melanoma and some carcinomas | |||
|- | |||
| Epithelioid cell | |||
| cell shape round/oval, nucleus round/oval, looks like epithelium (cell borders touch neighbouring cells - collectively form a barrier) | |||
| suggests epithelial lesion (carcinoma) - compatible with others | |||
|- | |||
| [[Small round blue cell tumour]]/lymphoid: | |||
| small cells with scant cytoplasm - usually round; "small" is classically 2x a "resting lymphocyte" diameter † | |||
| common in children; in adults often lymphoma | |||
|- | |||
| Small lymphoid ([[small cell lymphoma]]). | |||
| "small" in the context of lymphoid is classically ~1x a "resting lymphocyte" diameter; often not malignant by cytology | |||
| suggests [[small cell lymphoma]], reactive changes or infection | |||
|- | |||
| Plasmacytoid cell | |||
| resemble a plasma cell: eccentric nucleus, moderate basophilic cytoplasm, +/-"clockface" chromatin pattern (clumping of chromatin at the periphery of the nucleus), +/-perinuclear hof (crescentic cytoplasmic clearing adjacent to the nucleus; represents abundant Golgi apparatus | |||
| suggests [[plasma cell neoplasm]] or infection | |||
|} | |||
Note: | |||
*† Diameter of a "resting lymphocyte" ~ diameter of a [[red blood cell]] (RBC) ~ 8 micrometres. | |||
**Most carcinoma cells are 3-4x the size of a RBC. | |||
======Dyscohesive versus cohesive====== | ======Dyscohesive versus cohesive====== | ||